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TranscriptomicsGene expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21369 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21394 | biostudies-arrayexpress
TranscriptomicsSystems biology of interstitial lung diseases
This SuperSeries is composed of the following subset Series: GSE21369: Gene expression profiles of interstitial lung disease (ILD) patients GSE21394: MicroRNA expression profiles of interstitial lung disease (ILD) patients Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21411 | biostudies-arrayexpress
TranscriptomicsSerial Analysis of Gene Expression molecular signature for disease progression in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease that is unresponsive to current therapy. While it carries a median survival of less than 3 years its rate of progression varies widely between patients. We hypothesized that studying the gene express...
ORGANISM(S): Homo sapiens 
2009-04-07 | E-GEOD-11665 | biostudies-arrayexpress
MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
TranscriptomicsGene expression in lung fibroblasts
Pulmonary fibrosis is a chronic, progressive, and lethal interstitial lung disease. It is characterized by extracellular matrix deposition, fibroblast proliferation, and accumulation. Fibroblasts from normal or UIP histology were cultured and analyzed. Keywords: Fibroblasts from normal histology lun...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-10921 | biostudies-arrayexpress
TranscriptomicsscRNA-seq analysis of lung CD64-expressing mononuclear cells, patrolling and classical monocytes from steady-state C57BL/6J mice
We sought to evaluate in an unbiased way the heterogeneity of lung interstitial macrophages and their relationship with alveolar macrophages, lung Ly-6Chi classical monocytes and Ly-6Clo patrolling monocytes, by single cell RNA-Seq.
ORGANISM(S): Mus musculus 
2019-07-31 | E-MTAB-7678 | biostudies-arrayexpress
MetabolomicsPreliminary exploration of the ability of HUC-MSCs to restore the lung microbiota and related metabolite disorders in IPF treatment: Combining 16S sequencing and metabolite analysis

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive pulmonary disease, and effective therapies to reverse the natural course of IPF are lacking. A growing number of studies have shown that the use of human umbilical cord-derived mesenchymal stem cells (HUC-...

2025-09-01 | MTBLS12922 | MetaboLights
TranscriptomicsCharacterization of Lung MDSC from SKG mice
The purpose of this project is to characterize the myeloid derived suppressor cells (MDSCs) in the inflamed lung of interstitial lung disease SKG mice. We compared the gene expression of lung MDSCs with MDSCs from bone marrow or spleen.BD FACSAria III (BD Biosciences) was used to sort CD11b+Gr1+ cel...
ORGANISM(S): Mus musculus 
2026-03-31 | E-MTAB-16508 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics (Visium, 10x Genomics) data for human Idiopathic Pulmonary Fibrosis (IPF) and control lung tissue
Visium (10x Genomics) spatially resolved transcriptomics data generated from normal and Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma tissues collected from human donors. The fresh-frozen tissues that were analyzed were from four healthy control (HC) subjects and from four IPF patients. For ea...
ORGANISM(S): Homo sapiens 
2024-05-28 | E-MTAB-14121 | biostudies-arrayexpress
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