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MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
ProteomicsProteomic signatures of diffuse and intestinal subtypes of gastric cancer
Gastric cancer is a leading cause of death from cancer globally. Gastric cancer is classified into intestinal, diffuse and indeterminate subtypes based on histology according to the Laurén classification. The intestinal and diffuse subtypes, although different in histology, demographics and outcomes...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026279 | Pride
Proteomics Gastric cancer Mass spectrometry Intestinal gastric cancer Diffuse gastric cancer Signet ring cell carcinoma Lc-ms/ms 
TranscriptomicsGastric Cancer Subtyping (Australian Patient Cohort)
Genome-wide mRNA expression profiles of 70 primary gastric tumors from the Australian patient cohort. Like many cancers, gastric adenocarcinomas (gastric cancers) show considerable heterogeneity between patients. Thus, there is intense interest in using gene expression profiles to discover subtypes ...
ORGANISM(S): Homo sapiens 
2012-07-04 | E-GEOD-35809 | biostudies-arrayexpress
TranscriptomicsGastric Cancer Cell Lines
Regions of recurrent genomic amplification and deletion are frequently observed in primary gastric cancers (GC). However, identifying specific oncogenes and tumor suppressor genes within these regions can be challenging, as they often cover tens to hundreds of genes. Here, we combined high-resolutio...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-10611 | biostudies-arrayexpress
TranscriptomicsExpression data from Helicobacter pylori isolates infecting a gastric epithelial progenitor cell line
Helicobacter pylori clinical isolates can establish themselves in gastric epithelial stem cells and this interaction may have implications for gastric tumorigenesis. Mouse gastric epithelial progenitor cells (mGEPs) were infected for 24hrs with Helicobacter pylori clinical isolates Kx1 and Kx2. Kx1 ...
ORGANISM(S): Helicobacter pylori 
2010-05-26 | E-GEOD-10261 | biostudies-arrayexpress
TranscriptomicsEpigenetic analysis of gastric cancer cell lines
Genome wide DNA methylation profiling of gastric cancer cell lines. The Illumina Goldengate DNA methylation Beadchip was used to obtain DNA methylation profiles across 1,505 CpG CpGs in 20 gastric cancer cell lines. Bisulphite converted DNA from the 20 gastric cancer cell lines were hybridised to th...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-29499 | biostudies-arrayexpress
TranscriptomicsGenetic Landscape of Copy Number Alterations in Gastric Cancer
Genome-wide DNA copy number profiling of gastric tumors and matched non-maligant samples. The affymetrix SNP6 array was used to obtain DNA copy number profiles in 193 gastric tumors and 98 matched gastric non-malignant samples. Genomic DNA extracted from 193 gastric tumors and 98 matched gastric non...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-31168 | biostudies-arrayexpress
TranscriptomicsmicroRNA expressions in gastric cancer
The study was undertaken to identify microRNAs differently expressed by intestinal type of gastric cancer using miRNA microarray. The miRNA expression in the intestinal type of gastric cancer depending on H. pylori infection suggest that different gastric cancer pathogenesis could be exist between H...
ORGANISM(S): Homo sapiens 
2014-01-25 | E-GEOD-54397 | biostudies-arrayexpress
TranscriptomicsAgilent 400K aCGH data for 30 human gastric cancers
Copy number alteration (CNA) is a good signpost to identify cancer related genes. CNAs were analyzed using the Agilent 400K array comparative genomic hybridization (aCGH) in fresh-frozen tumor and matched normal tissues from 30 gastric cancer patients. Whole genomic CNAs in 30 human gastric cancers ...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-69266 | biostudies-arrayexpress
TranscriptomicsSynergistic Tumor Suppressor Activity of E-cadherin and p53 in a Conditional Mouse Model for Diffuse-Type Gastric Cancer
BACKGROUND & AIMS: Gastric cancer is the second most frequent cause of death from cancer in the world, diffuse-type gastric cancer (DGC) exhibiting a poor prognosis. Germline mutations of CDH1, encoding E-cadherin, have been reported in hereditary DGCs, and genetic and/or epigenetic alterations of C...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-25302 | biostudies-arrayexpress
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