Intestinal tissue repair

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Lab affiliation

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea (2)
Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee (1)
Institute of Cancer Research, London (1)
Laboratory of Cardiovascular Medicine, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padua, Italy (1)
Montana State University, Department of Microbiology and Cell Biology, Bozeman, MT (1)
Universitat de València, Facultad de Farmacia y Ciencias de la Alimentación, Área de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Valencia, Spain. (1)

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Keyword

Radiation-induced late intestinal injury, Rectal cancer, NCRT, TME, Phase separation (1)
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Nephropathic infantile cystinosis (1)
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Spinal Bulbar Muscular Atrophy (SBMA) (1)
Mucolipidosis (1)
Mitochondrial aminoacyl-tRNA synthetases (Mt-aaRS Disorders) (1)
Shine Syndrome (1)
Intestinal Bromhidrosis Syndrome (1)
Autosomal recessive extra oral halitosis (1)
CACNA1H mutation (1)
Dimethylglycine dehydrogenase deficiency (1)

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Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

Based on the hypothesis that, enhancing the local concentration of donor oligos could increase the correction rates, we generated and tested novel CRISPR-Cas9 systems, in which the DNA repair template is covalently conjugated to Cas9 (RNPD system). To validate our results from the HEK293T reporter c...

ORGANISM(S): Mus musculus

2018-06-04 | E-MTAB-6808 | biostudies-arrayexpress

RNA-seq analysis of crypt samples isolated from the small intestine of Bach2 KO and control mice

Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. Here, we found that Bach2 deficiency promotes the intestinal epithelial cell proliferation during homeostasis and facilitates the crypt regeneration after irradiation, resulting in a reduction of ...

ORGANISM(S): Mus musculus

2021-01-12 | E-MTAB-9865 | biostudies-arrayexpress

Gut-liver axis calibrates intestinal stem cell fitness via PEDF

The gut and liver have been recognized to mutually communicate through the biliary tract, portal vein and systemic circulation, but it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy, transcriptomics and proteomics profiling, we identified pigment epithel...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2023-03-03 | MSV000091409 | MassIVE

Group 3 innate lymphoid cells amplify YAP1-driven small intestinal repair

Ror gamma t-deficient mice lack group 3 Innate Lymphoid Cells (ILC3s) and as a result have increased tissue damage and diminished tissue repair in response to insult. To identify repair programs associated with ILC3 presence the transcriptomes of small intestinal stem cells exposed to damage in the ...

ORGANISM(S): Mus musculus

2018-06-29 | E-MTAB-6639 | biostudies-arrayexpress

Ribonucleotide excision repair prevents intestinal tumorigenesis

PRJNA436583 | ENA

Type III interferons induce pyroptosis in gut epithelial cells and impair tissue repair upon intestinal injury.

PRJNA1159204 | ENA

Type III interferons induce pyroptosis in gut epithelial cells and impair tissue repair upon intestinal injury.

PRJNA1160875 | ENA

Group 3 innate lymphoid cells amplify YAP1-driven small intestinal repair

PRJEB27369 | ENA

Regulation of intestinal immunity and tissue repair by enteric glia

PRJNA769057 | ENA