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ProteomicsSpatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma
The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we use...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-24 | PXD007052 | Pride
Intra-tumoral heterogeneity Liver Hepatocellular carcinoma 
ProteomicsIntra-tumor heterogeneity revealed by mass spectrometry im-aging is associated with the prognosis of breast cancer
Intra-tumor heterogeneity (ITH) results from coexistence of genetically distinct cancer cell (sub)populations, their phenotypic plasticity, and the presence of heterotypic components of the tumor microenvironment (TME). Here we addressed potential association between phenotypic ITH revealed by mass ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027878 | Pride
Her2-positive breast cancer  intra-tumor heterogeneity  mass spectrometry imaging  prognosis  long-term outcome  tumor microenvironment 
GenomicsMesoHET (Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma)
MesoHET (Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma)
PRJNA733511 | ENA
ProteomicsQuantification of Proteome heterogeneity in benign and malignant prostate tissues
Intra-tumor heterogeneity (ITH) has been studied at the morphologic, genomic, and transcriptomic level, but not proteomic level. Recent advances in mass spectrometric (MS) proteome quantification techniques, exemplified by SWATH-MS, a massively parallel targeting method, now also support precise qua...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD003497 | Pride
Intra-tumor heterogeneity  prostate cancer  pct-swath 
GenomicsIntra-Tumor DNA Methylation Heterogeneity in Glioblastoma Implications for DNA Methylation-based Classification
Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma Implications for DNA Methylation-based Classification
PRJNA478049 | ENA
TranscriptomicsIntra-tumor Genetic Heterogeneity in Rectal Canger
Colorectal cancer arises in part from the cumulative effects of multiple gene lesions. Recent studies in selected cancer types have revealed significant intra-tumor genetic heterogeneity and highlighted its potential role in disease progression and resistance to therapy. We hypothesized the existenc...
ORGANISM(S): Homo sapiens 
2015-09-24 | E-GEOD-73365 | biostudies-arrayexpress
TranscriptomicsProfiling by array of human Glioblastoma multiforme (GBM) tumor samples to asses the intra-tumoral heterogeneity in genomic copy number aberrations
Glioblastoma multiforme (GBM) is a highly heterogeneous disease that shows an wide range of genetic abnormalities in comparison to other astrocytic tumors. We have extracted between 4 and 8 tumor subsamples from different areas of the malignant tissue that were at least 1cm apart. Our aim to asses t...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1215 | biostudies-arrayexpress
GenomicsMulti-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma
Background:Malignant pleural mesothelioma (MPM) is a heterogeneous cancer. Better knowledge of molecular and cellular intra-tumor heterogeneity throughout the thoracic cavity is required to develop efficient therapies. This study focuses on molecular intra-tumor heterogeneity using the largest serie...
EGAS00001005328 | EGA
GenomicsPatterns of intra- and inter-tumor phenotypic heterogeneity in men with lethal prostate cancer [scRNA-seq]
Patterns of intra- and inter-tumor phenotypic heterogeneity in men with lethal prostate cancer [scRNA-seq]
PRJNA1236646 | ENA
GenomicsPatterns of intra- and inter-tumor phenotypic heterogeneity in men with lethal prostate cancer [scATAC-seq]
Patterns of intra- and inter-tumor phenotypic heterogeneity in men with lethal prostate cancer [scATAC-seq]
PRJNA1237369 | ENA
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