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MetabolomicsA pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella

Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge essential nutrients from the host has been an open question due to the difficulties in distinguishing between bacterial and host metabolites

2023-08-02 | MTBLS1275 | MetaboLights
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
TranscriptomicsDelineation of diverse macrophage activation programs in response to intracellular parasites and cytokines
To provide a global perspective on the relationships between macrophage activation programs and to understand how certain pathogens circumvent them, we used transcriptional profiling by genome wide microarray analysis to compare the responses of mouse macrophages following exposure to the intracellu...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-20087 | biostudies-arrayexpress
GenomicsMicrobiome-Derived RNA Promotes Heritable Defense Against Intracellular Pathogens in Caenorhabditis elegans
Microbiome-Derived RNA Promotes Heritable Defense Against Intracellular Pathogens in Caenorhabditis elegans
PRJNA1477917 | ENA
TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro THP-1 (ATCC TIB-202) cell line infection, comparing bacteria grown in host medium and intracellular bacteria recovered from infected THP-1 cells. Two-condition experiment, MAP-K vs. intracellular MAP-THP-1. Biolog...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress
ProteomicsA cullin-RING ubiquitin ligase promotes thermotolerance as part of the Intracellular Pathogen Response in C. elegans.
Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we described a physiological program in the nematode C. elegans called the Intracellular Pathogen Response (IPR), which promotes resistance to proteotoxic stress and appears to be distinct from canonical prote...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2020-02-07 | MSV000084936 | MassIVE
TranscriptomicsMicrobiome-Derived RNA Promotes Heritable Defense Against Intracellular Pathogens in Caenorhabditis elegans
Intestinal microbiota shape host immunity, but whether they can pre-activate defense against intracellular pathogens remains unclear. Here, we identify a natural microbiome member, Stenotrophomonas indicatrix JUb19, as the first example of a bacterium that partially induces the Intracellular Pathoge...
ORGANISM(S): Caenorhabditis elegans 
2026-06-17 | GSE335319 | GEO
TranscriptomicsLeishmania major modulates autophagy in host macrophages during intracellular differentiation
Autophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process. Protozoan parasites of the genus Leishmania are the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-52624 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in 23 Cryptococcus gattii isolates
An array analysis of C. gattii (C. bacillosporus), intended to identify loci associated with the hypervirulence of the Vancouver Island Outbreak (VIO). 23 C. gattii isolates, representing both VIO strains and control strains, were grown for 24 hours in mammalian macrophages. RNA was isolated and g...
ORGANISM(S): Cryptococcus bacillisporus 
2010-05-15 | E-GEOD-17052 | biostudies-arrayexpress
GenomicsThe McbR transcription factor links intracellular folate pool to virulence in enteric pathogens
The McbR transcription factor links intracellular folate pool to virulence in enteric pathogens
PRJNA1431516 | ENA
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