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ProteomicsUbiquitin mediated intracellular trafficking is required for Jam-C function
Endothelial cells form a barrier between the components present in the blood and the underlying tissue. Essential to formation of this barrier are junctional complexes present between cells. These complexes are dynamic, tightly regulated and remodel during key physiological processes such as inflamm...
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD013003 | Pride
Proteomics Intracellular trafficking Endothelial cells Jam-c Ubiquitin Lc-ms/ms 
ProteomicsProteomic dissection of nanoparticle-containing vesicles reveals a major role for a macropinocytic-like uptake mechanism and multivesicular bodies during intracellular nanoparticle trafficking
Rational design of nanocarriers for drug delivery approaches requires an unbiased knowledge of uptake mechanisms and intracellular trafficking pathways. Here we dissected these processes using a quantitative proteomics approach. We isolated intracellular vesicles containing superparamagnetic iron ox...
ORGANISM(S): Homo sapiens (Human) 
2014-09-25 | PXD001175 | Pride
Human Hdmse Dia Intracellular trafficking Hela Synapt g2s Nanoparticles Endosomes Vesicles 
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
GenomicsThe SON splicing factor is required for intracellular trafficking that promotes centriole assembly
The SON splicing factor is required for intracellular trafficking that promotes centriole assembly
PRJNA689788 | ENA
UnknownAtRMR1 functions as a cargo receptor for protein trafficking to the protein storage vacuole.
Not available
S-EPMC2171354 | biostudies-literature
ProteomicsDifferential intracellular trafficking of exosomes in microglia and astrocytes
Exosomes have emerged as key players in cell-to-cell communication in both physiological and pathological processes in the Central Nervous System. Thus far, the intracellular pathways involved in uptake and trafficking of exosomes within different cell types of the brain are poorly understood. In ou...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038287 | Pride
Brain-derived exosomes  α-synuclein ko mouse brain hemispheres (cd57bl6) 
ProteomicsO-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling
Ligand-stimulated epidermal growth factor receptor (EGFR) signaling plays fundamental roles in normal cell physiology, such as cell growth, cell proliferation, and cell survival. Deregulation of EGFR signaling contributes to the development and progression of diseases including cancer. Despite its e...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD031700 | Pride
Endosomal sorting Membrane receptors O-glcnacylation Egfr 
ProteomicsNutritional immunity promotes intracellular survival of nontypeable Haemophilus influenzae
Nutritional immunity promotes intracellular survival of nontypeable Haemophilus influenzae via altered intracellular trafficking
ORGANISM(S): Haemophilus Influenzae (ncbitaxon:727) 
2018-05-24 | MSV000082399 | MassIVE
UnknownIn vivo fate and intracellular trafficking of vaccine delivery systems.
Not available
S-EPMC9085465 | biostudies-literature
UnknownDrosophila VAMP7 regulates Wingless intracellular trafficking.
Not available
S-EPMC5655445 | biostudies-literature
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