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MetabolomicsCirculatory metabolomics reveals the association of the metabolites with clinical features in the patients with intrahepatic cholestasis of pregnancy

OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse pregnancy outcomes to the mother and fetus. As yet, the metabolic profiles and the association of the clinical features remain obscure.

METHODS: Fifty sev...

2022-03-01 | MTBLS2627 | MetaboLights
MetabolomicsGut Microbiota Dysbiosis is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

The co-occurrence of gut microbiota dysbiosis and bile acids (BAs) metabolism alteration has been reported in several human liver diseases. However, the gut microbiota dysbiosis in infantile cholestatic jaundice (CJ), and the linkage between gut bacterial changes and alterations of BAs metabolism...

2019-11-30 | MTBLS1295 | MetaboLights
ProteomicsProteomes of Placenta from Pregnant Women with Intrahepatic Cholestasis of Pregnancy
The iTRAQ analysis combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was performed to separate differentially expressed placental proteins from 4 pregnant women with ICP and 4 healthy pregnant women.
ORGANISM(S): Homo sapiens (Human) 
2021-09-24 | PXD028734 | Pride
Placenta Intrahepatic cholestasis of pregnancy Pregnancy Itraq 
GenomicsUnique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy
Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy
PRJNA867388 | ENA
Genomicsena-DATASET-UCAM-GEL-14-12-2018-10:45:29:339-40 - samples
Short read whole genome sequencing (WGS) CRAM files for the NIHR BioResource Rare Diseases WGS project.Participants from the Intrahepatic Cholestasis of Pregnancy (ICP) Rare Disease domain
EGAD00001004515 | EGA
ProteomicsPeptidomics Landscape of Intrahepatic Cholestasis of Pregnancy in vitro
Peptidomics Landscape of Intrahepatic Cholestasis of Pregnancy in vitro
ORGANISM(S): Homo Sapiens 
2025-03-20 | PXD062070 |
GenomicsH4K12 Lactylation-activated c-JUN signaling aggravates bile acid dysfunction in intrahepatic cholestasis during pregnancy
H4K12 Lactylation-activated c-JUN signaling aggravates bile acid dysfunction in intrahepatic cholestasis during pregnancy
PRJNA884413 | ENA
UnknownRisk of stillbirth in United States patients with diagnosed intrahepatic cholestasis of pregnancy.
Not available
S-EPMC10651178 | biostudies-literature
UnknownDistribution of endotoxin in maternal and fetal body with intrahepatic cholestasis of pregnancy and its association with adverse fetal outcome.
Not available
S-EPMC9733156 | biostudies-literature
GenomicsUnique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is strongly associated withan increased risk of adverse perinatal outcomes. Total bile acid (TBA) levels in the late second or third trimester are a major factor in the diagnosis. Here, we sought to establish the miRNA expression profile of plasma exosomes...
ORGANISM(S): Homo sapiens 
2022-08-09 | GSE210764 | GEO
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