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TranscriptomicsGene expression in canine uterine bacterial infection
The study was undertaken to analyze the effect of canine uterine bacterial infection (Pyometra) on local gene expression patterns in the uteri. The results show profound upregulation of various expected genes related to both the innate and innate immune system. In addition, there was a marked upregu...
ORGANISM(S): Canis lupus familiaris 
2010-08-20 | E-GEOD-17878 | biostudies-arrayexpress
TranscriptomicsStimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection
The nematode Caenorhabditis elegans offers currently untapped potential for carrying out high-throughput, live-animal screens of low molecular weight compound libraries to identify molecules that target a variety of cellular processes. We previously used a bacterial infection assay in C. elegans to...
ORGANISM(S): Caenorhabditis elegans 
2012-04-13 | E-GEOD-37266 | biostudies-arrayexpress
TranscriptomicsGenetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that factors on chromosomes (chr) 8, 11,...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-19668 | biostudies-arrayexpress
TranscriptomicsExpression data in response to Xoo. bacterial infection in rice
In response to bacterial infection, early transcriptional re-programming occurs in the host plant. We used microarrays to analyse the global transcriptomic response to Xoo. infection in a resistant rice cultivar (IR24). This was analysed in parallel with microarrays examining Xoo infection in a susc...
ORGANISM(S): Oryza sativa 
2013-02-20 | E-GEOD-43050 | biostudies-arrayexpress
TranscriptomicsInteractome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus
Relatively little is understood about the dynamics of global host–pathogen transcriptome changes that occur during bacterial infection of mucosal surfaces. To test the hypothesis that group A Streptococcus (GAS) infection of the oropharynx provokes a host transcriptome response, we performed genom...
ORGANISM(S): Macaca fascicularis 
2010-03-18 | E-GEOD-20262 | biostudies-arrayexpress
TranscriptomicsSalmonella typhimurium infection of zebrafish embryo
Characterization of the zebrafish embryonic host response to systemic bacterial infection with Salmonella typhimurium wild type strain (SL1027) and its isogenic LPS O-antigen mutant Ra (SF1592) by means of a time-resolved global expression analysis. All infection experiments were performed using mix...
ORGANISM(S): Danio rerio 
2010-05-22 | E-GEOD-13994 | biostudies-arrayexpress
TranscriptomicsThe Identification of Genetic Factors Influencing Susceptibility to Staphylococcus aureus Infection in mice susceptible and resistant to S. aureus infection
It has been shown that inbred strains of mice exhibit variable susceptibility to S. aureus infection, but the specific genes responsible for this differential phenotype are unknown. Using ISHM to identify genomic regions associated with the phenotypes, we considered genes within those interval to be...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-23584 | biostudies-arrayexpress
TranscriptomicsThe global transcriptional profile of Mycobacterium tuberculosis during human macrophages infection
During lung infection Mycobacterium tuberculosis (Mtb) resides in macrophages and subverts the bactericidal mechanisms of these professional phagocytes. In this work we have analyzed by DNA microarray technique the global transcription profile of Mtb infecting primary human macrophages in order to i...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-27 | E-GEOD-6209 | biostudies-arrayexpress
TranscriptomicsA Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response
Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate IFN-s...
ORGANISM(S): Homo sapiens 
2011-02-03 | E-GEOD-26414 | biostudies-arrayexpress
TranscriptomicsSpecificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection
Pathogenic mycobacteria have the ability to survive within macrophages and persist inside granulomas composed of host immune cells. The complex host-pathogen interactions that determine the outcome of a mycobacterial infection process result in marked alterations of the host gene expression profile....
ORGANISM(S): Danio rerio 
2010-05-15 | E-GEOD-15328 | biostudies-arrayexpress
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