Intron retention

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Genome-wide analysis of gene expression and intron retention during development in a U12-type splicing-deficient zebrafish mutant [RNA-seq]

To determine the global impact of the clbn mutation on gene expression and efficiency of U2- and U12-type splicing, we analyzed the transcriptome of 108hpf wt and clbn mutant larvae by microarrays and RNA sequencing. RNAseq data was used to characterize intron retention of U2-type and U12-type intro...

ORGANISM(S): Danio rerio

2014-02-05 | E-GEOD-53758 | biostudies-arrayexpress

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins is activated during neurogenesis, but the unde...

ORGANISM(S): Mus musculus

2012-07-12 | E-GEOD-37933 | biostudies-arrayexpress

Intron retention analysis using isogrowth profiling

PRJNA648363 | ENA

Reactive astrocytes in ALS display dysregulated intron retention

Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human iPSC-derived astrocytes carrying VCP, C9orf72 and SOD1 ALS-causing mutations as well as ...

ORGANISM(S): Homo sapiens (Human)

2021-09-09 | PXD022604 | Pride