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ProteomicsINTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double- strand breaks
This study shows that Integrator complex subunit 6 (INTS6) associates with the trimeric SOSS1 (comprising INTS3, INIP, and hSSB1) to form a tetrameric SOSS1 complex following DNA damage. INTS6 binds to DNA:RNA hybrids and plays a crucial role in Protein Phosphatase 2 (PP2A) recruitment to DNA double...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048694 | Pride
Ints6setx Ints6 Int6 complex 
ProteomicsRNAPII interactome in INTS6 degron cells
In this study we show that acute INTS6 depletion remodels the RNAPII interactome and enhances ARMC5 binding, the same as what we observed in Ints6 KO cells. To investigate how acute INTS6 depletion affects RNAPII function, we determined the RNAPII interactome in the the Ints6 degron cells. Chromatin...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD053351 | Pride
Transcription Ints6 Chromatin Rna-polymerase ii 
ProteomicsRNAPII interactome in INTS6 KO and WT cells
In this study we show that INTS6 KO remodels the RNAPII interactome and enhances ARMC5 binding. To investigate how INTS6 affects RNAPII function, we determined the RNAPII interactome in the presence and absence of INTS6 using Ints6 KO cells. Chromatin fractions from WT and INTS6 KO cells, with or wi...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD053346 | Pride
Transcription Ints6 Chromatin Rna-polymerase ii 
GenomicsINTS6 controls DNA:RNA hybrids autoregulation at double-strand break through Senataxin
INTS6 controls DNA:RNA hybrids autoregulation at double-strand break through Senataxin
PRJNA1034504 | ENA
TranscriptomicsPseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma [miRNA]
To identify the novel tumor suppressors in hepatocellular carcinoma (HCC), we have employed whole genome microarray expression profiling as a discovery platform in HCC and paired normal liver tissues to identify genes which down-regulated in HCC. Among which, INTS6 and its pseudogene, namely INTS6P1...
ORGANISM(S): Homo sapiens 
2015-01-03 | E-GEOD-64632 | biostudies-arrayexpress
TranscriptomicsPseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma [mRNA, lncRNA]
To identify the novel tumor suppressors in hepatocellular carcinoma (HCC), we have employed whole genome microarray expression profiling as a discovery platform in HCC and paired normal liver tissues to identify genes which down-regulated in HCC. Among which, INTS6 and its pseudogene, namely INTS6P1...
ORGANISM(S): Homo sapiens 
2015-01-03 | E-GEOD-64631 | biostudies-arrayexpress
GenomicsEffect of overexpression of IntS6 and IntS12 on gene expression in Drosophila DL1 cells
Effect of overexpression of IntS6 and IntS12 on gene expression in Drosophila DL1 cells
PRJNA929230 | ENA
UnknownDisrupting integrator complex subunit INTS6 causes neurodevelopmental disorders and impairs neurogenesis and synapse development.
Not available
S-EPMC12618080 | biostudies-literature
OtherINTS6 controls DNA:RNA hybrids autoregulation at double-strand break through Senataxin
The fidelity of transcription is essential for genome stability, especially when DNA damage happens. However, how the transcription cycle is regulated remains unknown. Here, we found that INTS6 is a fundamental player, which recruits PP2A to double-strand breaks (DSBs) and functions together with se...
ORGANISM(S): Homo sapiens 
2024-10-18 | GSE246729 | GEO
UnknownTetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks.
Not available
S-EPMC11602137 | biostudies-literature
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