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TranscriptomicsGenome-wide expression profiling revealed peripheral effects of CB1 inverse agonists in improving insulin sensitivity and metabolic parameters
Inhibition of cannabinoid receptor 1 (CB1) has shown efficacy in reducing body weight and improving metabolic parameters, with the effects correlating with target engagement in the brain. Recently, the peripheral effects of inhibiting the CB1 receptor has been appreciated through studies in diet-ind...
ORGANISM(S): Mus musculus 
2010-06-21 | E-GEOD-21069 | biostudies-arrayexpress
TranscriptomicsRecovery of phenotypes obtained by adaptive evolution through inverse metabolic engineering
Reconstructed mutants of yeast by inverse metabolic engineering were characterized by fermentation physiology and tools from systems biology. Six reconstructed mutants of yeast were grown on aerobic batch with galactose as carbon source
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-29 | E-GEOD-36118 | biostudies-arrayexpress
UnknownExpanding the Scope of RNA Metabolic Labeling with Vinyl Nucleosides and Inverse Electron-Demand Diels-Alder Chemistry.
Not available
S-EPMC8061575 | biostudies-literature
UnknownThe Efficiency of Metabolic Labeling of DNA by Diels-Alder Reactions with Inverse Electron Demand: Correlation with the Size of Modified 2'-Deoxyuridines.
Not available
S-EPMC10204056 | biostudies-literature
ProteomicsStructure–Function Relationships and Therapeutic Potential of Non-Covalent PPARγ Inverse Agonists
Peroxisome proliferator-activated receptor gamma (PPARγ) is a validated therapeutic target for type 2 diabetes (T2D), but current FDA-approved agonists such as the glitazones are limited by adverse effects. SR10171, a non-covalent partial inverse agonist with modest binding potency, improves insulin...
ORGANISM(S): Homo sapiens (Human) 
2025-11-15 | PXD066095 | Pride
UnknownMetabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides.
Not available
S-EPMC9389531 | biostudies-literature
TranscriptomicsRNA-seq with metabolic labelling of human breast cancer cell line MCF7 treated with a panel of 40 different cancer drugs and untreated controls
This experiment has utilized metabolic labeling coupled with RNA-sequencing to identify directly responding genes after perturbing breast cancer targets.
ORGANISM(S): Homo sapiens 
2025-03-05 | E-MTAB-14924 | biostudies-arrayexpress
ProteomicsBroadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene–Tetrazine Click Chemistry
Bio-orthogonal chemistry has gained widespread use in the study of many biological systems of interest, including protein prenylation. Prenylation is a post-translational modification in which a 15 or 20 carbon isoprenoid chain is transferred onto a cysteine near the C-terminus of a target protein. ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD045277 | Pride
Prenylation Lfq Click chemistry 
UnknownA Meta-Analysis of Food Labeling Effects on Consumer Diet Behaviors and Industry Practices.
Not available
S-EPMC6340779 | biostudies-literature
UnknownCyclopropene derivatives of aminosugars for metabolic glycoengineering.
Not available
S-EPMC6423581 | biostudies-literature
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