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ProteomicsA Quantitative Chemical Proteomics Approach Using a Novel Two-Probe System Enables System-Wide Analysis of Protein Prenylation
Proteins prenylation, the post-translational attachment of a farnesyl or geranylgeranyl isoprenoid to one or more C-terminal cysteine residues, is an important modulator of localization and function of proteins such as the Ras isoforms, and a widely studied therapeutic target in number of cancer and...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-03-29 | PXD009155 | Pride
Human Prenylation Chemical proteomics 
ProteomicsIn vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer’s disease reveals increased prenylation of a key set of proteins
Dysregulated prenylation has been implicated in the many diseases, including Alzheimer’s disease (AD). Prenylomic analysis, the combination of metabolic incorporation of an isoprenoid analogue (C15AlkOPP) into prenylated proteins with a bottom-up proteomic analysis, has allowed identification of pre...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-28 | PXD032350 | Pride
Altzhimer's disease Brain Prenylation Prenylomics Mice 
UnknownUncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition.
Not available
S-EPMC12315405 | biostudies-literature
GenomicsProtein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Pggt1b_ATACseq]
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Pggt1b_ATACseq]
PRJNA667026 | ENA
GenomicsProtein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Fntb_ATACseq]
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Fntb_ATACseq]
PRJNA667029 | ENA
UnknownDual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.
Not available
S-EPMC6544531 | biostudies-literature
TranscriptomicsSparse feature selection methods identify unexpected global cellular response to strontium-containing materials
Despite the increasing sophistication of biomaterials design and functional characterization studies, little is known regarding cells' global response to biomaterials. Here, we combined nontargeted holistic biological and physical science techniques to evaluate how simple strontium ion incorporation...
ORGANISM(S): Homo sapiens 
2018-11-25 | E-MTAB-7384 | biostudies-arrayexpress
GenomicsProtein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Pggt1b_ATACseq]
An interplay between immune signals, isoprenoids-mediated protein prenylation, and intracellular signaling for the differentiation and maintenance of eTreg cells.
ORGANISM(S): Mus musculus 
2021-01-20 | GSE158921 | GEO
GenomicsProtein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Fntb_ATACseq]
An interplay between immune signals, isoprenoids-mediated protein prenylation, and intracellular signaling for the differentiation and maintenance of eTreg cells.
ORGANISM(S): Mus musculus 
2021-01-20 | GSE158920 | GEO
UnknownProtein Prenylation in Plant Stress Responses.
Not available
S-EPMC6866125 | biostudies-literature
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