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ProteomicsThinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1
Protein lipidation is a post-translational modification that confers hydrophobicity on protein substrates to control their cellular localization, mediate protein trafficking, and regulate protein function. In particular, protein prenylation is a C-terminal modification on proteins bearing canonical ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-06 | PXD036365 | Pride
Prenyaltion Lipidation Aldh9a1 Prenylomics Proteomics 
ProteomicsIn vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer’s disease reveals increased prenylation of a key set of proteins
Dysregulated prenylation has been implicated in the many diseases, including Alzheimer’s disease (AD). Prenylomic analysis, the combination of metabolic incorporation of an isoprenoid analogue (C15AlkOPP) into prenylated proteins with a bottom-up proteomic analysis, has allowed identification of pre...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-28 | PXD032350 | Pride
Altzhimer's disease Brain Prenylation Prenylomics Mice 
ProteomicsMultilevel changes in the Mevalonate Pathway in Reduced Autophagy Aging Skeletal Muscle Cell Models
Autophagy is an essential cellular pathway that maintains homeostasis in the cell and healthy function overtime. Decline in autophagy function with age has been observed in skeletal muscle which leads to deterioration of muscle function. Defective autophagy has been linked with a reduction in the po...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-12 | PXD037896 | Pride
Prenyaltion Atg7 Prenylomics Autophagy Proteomics Mevalonate pathway 
ProteomicsAn alkyne-containing isoprenoid analogue based on a farnesyl diphosphate scaffold is a biologically functional universal probe for proteomic analysis
Prenylation consists of the modification of proteins with either farnesyl diphosphate (FPP) or geranylgeranyl diphosphate (GGPP) at a cysteine near the C-terminus of target proteins to generate thioether-linked lipidated proteins. Given the widespread involvement of prenylation in protein localizati...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD055402 | Pride
Prenylation Prenylomics Chemical probes Post-translational modifications 
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