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MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
GenomicsPrediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients
We investigated a panel of 21 genes by parallel sequencing on the Ion Torrent Personal Genome Machine platform. We sequenced 65 CRCs that were treated with cetuximab or panitumumab ( 37 samples were responsive and 28 were resistant).
ORGANISM(S): Homo sapiens 
2015-10-22 | E-MTAB-3883 | biostudies-arrayexpress
TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
GenomicsP300 ChIP-Seq analysis of PC3 cells treated with MnTE-2-PyP or not 24 hours prior to irradiation of 20 Gy.
In order to identify how MnTE-2-PyP affects p300 association to chromatin genome-wide, we performed a p300 chromatin Immunoprecipitation assay followed by Next Generation Sequencing on PC3 cells treated with or without MnTE-2-PyP one hour post-irradiation (Figure 3A). Based on the called peaks near ...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-74351 | biostudies-arrayexpress
UnknownA direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement.
Not available
S-EPMC6768898 | biostudies-literature
UnknownIon-Channel Proteins in the Prepubertal Bitch Reproductive System: The Immunolocalization of ASIC2, ASIC4, and PIEZO2.
Not available
S-EPMC12072602 | biostudies-literature
UnknownCarbon footprint distributions of lithium-ion batteries and their materials.
Not available
S-EPMC11603021 | biostudies-literature
MetabolomicsBenthic exometabolites and their ecological significance on threatened Caribbean coral reefs (Metabolite collection incubation assays)

Benthic organisms sustain coral reefs through their growth and metabolism, but less is known about how their released metabolites influence reef seawater microorganisms. To investigate metabolite composition of benthic exudates and their ecological significance for reef microbial communities, we ...

2022-08-22 | MTBLS2855 | MetaboLights
MetabolomicsQuantitative profiling of endocannabinoids in lipoproteins by LC–MS/MS
Endocannabinoids belong to a diverse family of endogenous lipid bioregulators acting as physiological ligands of cannabinoid receptor type 1 and cannabinoid receptor type 2 in the central and peripheral nervous system. They are also present in nmol/l concentrations in human blood plasma; however, th...
2015-03-11 | MTBLS163 | MetaboLights
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