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MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
TranscriptomicsStability selection for regression-based models of transcription factor-DNA binding specificity
Motivation: The DNA binding specificity of a transcription factor (TF) is typically represented using a position weight matrix (PWM) model, which implicitly assumes that individual bases in a TF binding site contribute independently to the binding affinity, an assumption that does not always hold. F...
ORGANISM(S): Homo sapiens 
2013-05-17 | E-GEOD-47026 | biostudies-arrayexpress
TranscriptomicsQuantitative modeling of transcription factor binding specificities using DNA shape
Accurate predictions of the DNA binding specificities of transcription factors (TFs) are necessary for understanding gene regulatory mechanisms. Traditionally, predictive models are built based on nucleotide sequence features. Here, we employed three- dimensional DNA shape information obtained on a ...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-59845 | biostudies-arrayexpress
TranscriptomicsProteinM-bM-^HM-^RDNA binding in the absence of specific base-pair recognition
Until now, it has been reasonably assumed that specific base-pair recognition is the only mechanism controlling the specificity of transcription factor (TF)M-bM-^HM-^RDNA binding. Contrary to this assumption, here we show that nonspecific DNA sequences possessing certain repeat symmetries, when pres...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-61920 | biostudies-arrayexpress
GenomicsQuantitative modeling of transcription factor binding specificities using DNA shape
The SELEX-seq platform was used to generate DNA-binding affinity predictions for the human Max transcription factor. This experiment was performed as part of a cross-validation study comparing the accuracy of DNA shape-augmented TF binding specificity models across two different platforms (SELEX-se...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-60200 | biostudies-arrayexpress
ProteomicsIdentification of proteolytic fragments of human hemoglobin
The uploaded data is related to the identification of the antibacterial/antiviral human peptide HBB 12-147 in hemoglobin digestion with Napsin-A
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-15 | MSV000086600 | MassIVE
ProteomicsHB digestion with Pepsin and Napsin
HB digestion with Pepsin and Napsin t=20, 60 and 120 min Analysis by nanoLC-ESI-iTRAP-OrbiTrap
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-10 | MSV000087400 | MassIVE
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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