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TranscriptomicsThe acute milk yield response to frequent milking in early lactation is mediated by genes transiently regulated by milk removal.
Milking dairy cows four times daily (4X) instead of twice daily (2X) during early lactation stimulates an increase in milk yield that partly persists through late lactation; however, the mechanisms behind this response are unknown. We hypothesized that the acute mammary response to regular milkings...
ORGANISM(S): Bos taurus 
2012-02-27 | E-GEOD-27380 | biostudies-arrayexpress
TranscriptomicsComparison of the effects of Tris (2-ethylhexyl) trimellitate (TOTM) on gene expression associated with testicular maldevelopment (TMD) in male rat foetal testes by transcription profiling
The purpose of this study is to assess the potential of TOTM to induce testicular maldevelopment in the rat. We studied the effects of TOTM on the expression of genes in pathways involved in steriodogenesis and testes development. Certain phthalate esters have previously been shown to be involved in...
ORGANISM(S): Rattus norvegicus 
2012-10-30 | E-GEOD-41901 | biostudies-arrayexpress
TranscriptomicsEphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts
With the aim of identifying new pathways and genes regulated by PTH(1-34) and PTH-related protein 1-141 [PTHrP(1-141)] in osteoblasts, this study was carried out using a mouse marrow stromal cell line, Kusa 4b10, that acquires features of the osteoblastic phenotype in long-term culture conditions. A...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-45895 | biostudies-arrayexpress
ProteomicsSuccinyl-CoA synthetase deficiency in mouse forebrain results in hyper-succinylation with perturbed neuronal transcriptional regulation and metabolism
Lysine-succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the TCA cycle. Deficiency of succinyl-CoA synthetase (SCS), the TCA-cycle enzyme catalyzing the reversible conversion of succinyl-CoA to succinate, leads to mitochondrial encephalomyopathy ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-21 | MSV000089697 | MassIVE
TranscriptomicsThe transcriptional response of mouse uterus to estrogen is genetically regulated
The growth and development of the uterus in response to 17β-estradiol (E2) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous work from our laboratory using inbred mice that are high (C57BL6/J; B6) or low (C3H/HeJ; C3H) responders to E2 has led ...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-38800 | biostudies-arrayexpress
ProteomicsFission yeast Caprin protein is required for efficient heterochromatin establishment.
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving histone methylation and non-coding RNAs. However,...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-02-14 | PXD050937 | Pride
Caprin Shotgun proteomics Schizosaccharomyces pombe Rna Heterochromatin Label-free quantitation 
TranscriptomicsIntegrating chromosomal aberrations and gene expression profiles to dissect rectal cancer
Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma tissue and that loss of 1q was related to lymph node metastasis. In order to find markers f...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12225 | biostudies-arrayexpress
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
TranscriptomicsDNA methylation profiling in colon cancer
Profiling of CpG island methylation in 19 primary colon cancer and paired normal samples Agilent 244k CpG island microarray
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-39334 | biostudies-arrayexpress
TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (piRNA and endo-siRNAs)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59254 | biostudies-arrayexpress
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