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Proteomics1 Identification of replisome-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry
Replication of the eukaryotic genome requires the assembly of thousands of replisomes that must work in concert to accurately replicate a cell’s genetic and epigenetic information. Defining replisome-associated proteins is a key step in understanding how genomes are replicated and repaired in the co...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-01-27 | PXD031165 | Pride
Dna replication Embryogenesis Drosophila Genome stability Replication fork 
ProteomicsiPOND mass sepctrometry (iPOND-MS) in BRCA1-A complex deficient cells treated with CPT in combination with an ATM inhibitor
iPOND Mass spectrometry (iPOND-MS) was performed to identify replication fork proteome in wild type (WT) and ABARAXAS KO (ABX KO) HEK293T cells treated with 1 µM CPT in combination with 250 nM ATM inhibitor (AZD0156). An additional set of control cells were kept for no-click (NC) negative control. T...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD077767 | Pride
UnknownProteome profiling of polyomavirus nuclear replication centers using iPOND.
Not available
S-EPMC11575236 | biostudies-literature
ProteomicsImpact of PARG Activity on the replisome composition
ADP-ribosylation is a posttranslational modification of proteins catalyzed by the PARP enzymes and removed by the enzyme PARG. In this project, we examined the impact of PARG activity on the recruitment of proteins to nascent DNA using iPOND-SILAC mass spectrometry. PARG was inhibited by treatment w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069827 | Pride
Ipond  adp-ribosylation  parg  dna replication 
UnknownIdentification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry.
Not available
S-EPMC9050644 | biostudies-literature
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD036236 | Pride
Tmt Proteomics 
ProteomicsProteome Profiling of Polyomavirus Nuclear Replication Centers Using iPOND
Polyomaviruses (PyVs) cause diverse diseases in a variety of mammalian hosts. During the life cycle, PyVs recruit nuclear host factors to viral genomes to facilitate replication and transcription. While host factors involved in DNA replication, DNA damage sensing and repair, and cell cycle regulatio...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-07 | PXD055210 | Pride
Proteome murine polyomavirus replication 
ProteomicsiPOND analysis of samples from WT and RNF4 knockout B cells
iPOND analysis of samples from WT and RNF4 knockout B cells
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-13 | MSV000093660 | MassIVE
ProteomicsAdenovirus remodeling of the host proteome and of host factors associating with viral genomes
Viral infections are associated with extensive remodeling of the cellular proteome. Viruses encode gene products that manipulate host proteins to redirect cellular processes or subvert antiviral immune responses. One way in which host antiviral proteins antagonize viral infection is by associating w...
ORGANISM(S): Viruses Homo sapiens (Human) 
2021-08-11 | PXD025339 | Pride
Intrinsic defense Dna virus Ipond Virus infection Adenovirus 
ProteomicsProteomic profiling of UV damage repair patches
DNA damage compromises not only genome stability but also the integrity of the chromatin template, which plays a central role in controlling cell identity. Our understanding of chromatin repair mechanisms is very incomplete. To bridge this knowledge gap, here we devised a novel proteomic strategy to...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD055129 | Pride
Uv damage repair Chromatin Ipond Nanolc-ms/ms 
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