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ProteomicsTyrosine phosphorylation of IQGAP1 in the MET pathway
Mass spectrometry was used to determine that cellular IQGAP1 and IQGAP2 proteins are phosphorylated at multiple tyrosine residues upon sodium orthovanadate treatment.
ORGANISM(S): Human 
MSV000086088 | MassIVE
ProteomicsTyrosine phosphorylation of IQGAP1 in the MET pathway
Mass spectrometry was used to determine IQGAP1 is a substrate of MET and c-Src, and is phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src cellular activity.
ORGANISM(S): Human 
MSV000086089 | MassIVE
ProteomicsThe Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
Proteomic data from pulldown performed with the recombinant Campylobacter CiaD-GST fusion was expressed in E. coli BL21(DE3) on a lysate of human cultured INT 407 cells. One non-specific binding control was performed on INT 407 cell lysates and two-pulldowns were realized with the recombinant protei...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-05 | MSV000086662 | MassIVE
ProteomicsIQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
A constant communication between mitochondria and nucleus ensures cellular homeostasis and adaptation to mitochondrial stress. Anterograde regulatory pathways involving a large number of nuclear-encoded proteins control mitochondrial biogenesis and functions. Such functions are deregulated in cancer...
ORGANISM(S): Homo sapiens (Human) 
2023-08-04 | PXD038314 | Pride
Alternative splicing  mitochondrial respiratory complex i  gastric cancer Lfq proteomics 
TranscriptomicsIQGAP1 Scaffold-Kinase Interaction Blockade Selectively Targets Ras-MAP Kinase Driven Tumors
MAPK scaffolds, such as IQGAP1, assemble pathway kinases together to effect signal transmission and disrupting scaffold function therefore offers a potentially orthogonal approach to MAPK cascade inhibition. Consistent with this possibility, we observed an IQGAP1 requirement in Ras-driven tumorigene...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44967 | biostudies-arrayexpress
GenomicsBulk RNA-sequencing of pooled 53 hpf wild-type and iqgap1-/- hemorrhage-positive mutant embryos
Bulk RNA-sequencing of pooled 53 hpf wild-type and iqgap1-/- hemorrhage-positive mutant embryos
PRJNA1462852 | ENA
ProteomicsSet 2: IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
A constant communication between mitochondria and nucleus ensures cellular homeostasis and adaptation to mitochondrial stress. Anterograde regulatory pathways involving a large number of nuclear-encoded proteins control mitochondrial biogenesis and functions. Such functions are deregulated in cancer...
ORGANISM(S): Homo sapiens (Human) 
2023-08-04 | PXD038331 | Pride
Alternative splicing  mitochondrial respiratory complex i  gastric cancer 
TranscriptomicsIQGAP1 serves a role in erlotinib-related purpuric dermatitis
IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) mediates erlotinib-related purpuric dermatitis.
ORGANISM(S): Homo sapiens 
2018-09-30 | GSE86975 | GEO
TranscriptomicsIQGAP1 Scaffold-Kinase Interaction Blockade Selectively Targets Ras-MAP Kinase Driven Tumors
MAPK scaffolds, such as IQGAP1, assemble pathway kinases together to effect signal transmission and disrupting scaffold function therefore offers a potentially orthogonal approach to MAPK cascade inhibition. Consistent with this possibility, we observed an IQGAP1 requirement in Ras-driven tumorigene...
ORGANISM(S): Mus musculus 
2013-04-01 | GSE44967 | GEO
GenomicsIQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
PRJNA902759 | ENA
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