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TranscriptomicsExpression data from IRE1a or XBP1 deficient mouse liver
IRE1a and XBP1 are key regulators of the unfolded protein response (UPR). XBP1 ablation causes profound hypolipidemia in mice, and triggers feedback activation of its upstream enzyme IRE1a, instigating regulated IRE1-dependent decay (RIDD), an mRNA degradation mechanism dependent on IRE1a's endoribo...
ORGANISM(S): Mus musculus 
2012-10-17 | E-GEOD-40515 | biostudies-arrayexpress
TranscriptomicsEffect of the IRE1a-XBP1 pathway inhibition during T helper 2 differentiation
The purpose of the study was to examine the role of the IRE1a-XBP1 pathway during Th2 lymphocyte activation and differentiation. In vitro Th2 cells were treated with 4μ8c, a drug that specifically inhibits IRE1a endonuclease activity, and transcriptomes were compared.
ORGANISM(S): Mus musculus 
2018-07-20 | E-MTAB-6894 | biostudies-arrayexpress
TranscriptomicsExpression data from primary hepatocytes knocking down or overexpressing IRE1a
The ER-resident protein kinase/endoribonuclease IRE1 is activated through trans-autophosphorylation in response to protein folding overload in the ER lumen and maintains ER homeostasis by triggering a key branch of the unfolded protein response. Here we show that mammalian IRE1a in liver cells is al...
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-31638 | biostudies-arrayexpress
Transcriptomicsire1 double mutant vs wild-type in response to tunicamycin
Arabidopsis thaliana wild-type and ire1a/ire1b double mutant plants were treated with tunicamycin. RNA was extracted and subjected to microarray analysis.
ORGANISM(S): Arabidopsis thaliana 
2012-03-13 | E-MEXP-3186 | biostudies-arrayexpress
ProteomicsBioID-based IRE1 interac-tome reveals participants of the ERAD machinery in the human mast cell leukemia cell line HMC-1.2
Investigation of the interactome of IRE1a and its relation to ERAD machinery
ORGANISM(S): Homo sapiens (Human) 
2024-04-29 | PXD047343 | Pride
Lc-ms. interactome ire1a Human Mast cell 
GenomicsRibo-seq analysis in HEK293A cells with or without IRE1a knockdown
Ribo-seq analysis in HEK293A cells with or without IRE1a knockdown
PRJNA822351 | ENA
UnknownIRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis.
Not available
S-EPMC7666601 | biostudies-literature
GenomicsEffect of the IRE1a-XBP1 pathway inhibition during T helper 2 differentiation
Effect of the IRE1a-XBP1 pathway inhibition during T helper 2 differentiation
PRJEB27378 | ENA
TranscriptomicsExpression data from primary hepatocytes knocking down or overexpressing IRE1a
The ER-resident protein kinase/endoribonuclease IRE1 is activated through trans-autophosphorylation in response to protein folding overload in the ER lumen and maintains ER homeostasis by triggering a key branch of the unfolded protein response. Here we show that mammalian IRE1a in liver cells is al...
ORGANISM(S): Mus musculus 
2011-08-31 | GSE31638 | GEO
GenomicsTranscriptomic analysis of glioblastoma cells bearing different IRE1a mutants
Transcriptomic analysis of glioblastoma cells bearing different IRE1a mutants
PRJNA421725 | ENA
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