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TranscriptomicsTranscription profiling of primary fibroblasts from a family with autosomal recessive Hutchinson-Gilford Progeria Syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina. By studying a family with homozygous LMNA mutation (K542N), we s...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-MEXP-3097 | biostudies-arrayexpress
TranscriptomicsPlatform Comparison Study
Microarray technology is a powerful tool able to measure RNA expression for thousands of genes at once. Various studies have been published comparing competing platforms with mixed results: some find agreement, others do not. As the number of researchers starting to use microarrays and the number of...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2521 | biostudies-arrayexpress
TranscriptomicsPerformance Evaluation of Commercial miRNA Expression Array Platforms
This data is part of a miRNA platform comparison study. We compared the performance characteristics of four commercial miRNA array technologies and found that all platforms performed well in separate measures of performance. The Ambion and Agilent platforms were more accurate, whereas the Illumina ...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-19248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human normal pre-frontal cortex, liver, and colon tissues and colon tumors
DNA methylation, at CpG islands and promoters, is often inversely correlated with gene expression. We used expression microarrays to determine the relationship between DNA methylation and gene expression in 5 normal prefrontal cortex samples and 5 normal liver samples from the same individuals as we...
ORGANISM(S): Homo sapiens 
2009-01-23 | E-GEOD-13471 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from non-immortalized lymphocyte samples from participants of the AGES Reykjavik Study
Genome-wide DNA methylation was studied to identify regions with extreme inter-individual variability, half of which show stability within-person, and some of which show covariation with body mass index consistently and are located in or near genes previously implicated in regulating body weight or ...
ORGANISM(S): Homo sapiens 
2010-09-14 | E-GEOD-23858 | biostudies-arrayexpress
TranscriptomicsThe Transposon Insertion site Profiling Chip (TIP-chip)
We have developed a microarray intended for use in finding all transposons in a region of interest. By selectively amplifying and hybridizing transposon flanking DNA to our array, we can localize all transposons in the region present on our TIP-chip, a dense tiling array. We have tested our technolo...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-5646 | biostudies-arrayexpress
TranscriptomicsLarge organized chromatin K9-modifications (LOCKs) distinguish differentiated from embryonic stem cells
Higher eukaryotes must adapt a totipotent genome to specialized cell types with a stable but limited repertoire of functions. One potential mechanism for lineage restriction is changes in chromatin, and differentiation-related chromatin changes have been observed for individual genes. We have taken ...
ORGANISM(S): Mus musculus 
2009-01-17 | E-GEOD-13445 | biostudies-arrayexpress
TranscriptomicsA comprehensive methylome map of lineage commitment from hematopoietic progenitors
Epigenetic modifications must underlie lineage-specific differentiation since terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged. Hematopoiesis provides a well-defined model of progressive differentiation in which to study the role of epigenetic modifi...
ORGANISM(S): Mus musculus 
2010-08-15 | E-GEOD-20244 | biostudies-arrayexpress
TranscriptomicsNID2 and HOXA9 promoter hypermethylation as biomarkers to prevent and detect Oral Cavity Squamous Cell Carcinoma
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadCh...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-28217 | biostudies-arrayexpress
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