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TranscriptomicsTranscriptome analysis of MENXM-bM-^@M-^Qassociated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas
Gonadotroph adenomas comprise 15M-bM-^@M-^S40 % of all pituitary tumors, are usually non-functioning and are often large and invasive at presentation. Surgery is the first-choice treatment, but complete resection is not always achieved, leading to high recurrence rates. As gonadotroph adenomas poorl...
ORGANISM(S): Rattus norvegicus 
2013-07-10 | E-GEOD-23207 | biostudies-arrayexpress
TranscriptomicsMET after transient Twist activation results in de novo gain of malignant traits
During Epithelial-Mesenchymal Transition (EMT), apical-basal polarized epithelial cells are converted to front-to-back polarized mesenchymal cells that only form loose cell-cell adhesions. These phenotypic changes are accompanied by acquisition of increased motility and invasiveness. EMT programs ar...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-61206 | biostudies-arrayexpress
TranscriptomicsSimple Derivation of Transgene-Free iPS Cells by a Dual Recombinase Approach
Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by the introduction of the transcription factors Oct4, Sox2, Klf4 and cMyc using various methods. Here, we describe a new approach for the derivation of murine iPSCs using a polycistronic non-viral inducible vector integrated i...
ORGANISM(S): Mus musculus 
2014-03-29 | E-GEOD-51605 | biostudies-arrayexpress
TranscriptomicsThe transcription factor Otx2 regulates choroid plexus development and function
The choroid plexuses (ChPs) are the main regulators of cerebrospinal fluid (CSF) composition and thereby also control the composition of a principal source of signaling molecules that is in direct contact with neural stem cells in the developing brain. The regulators of ChP development mediating the...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-27630 | biostudies-arrayexpress
TranscriptomicsNutritional Strategy to Prevent Fatty Liver and Insulin Resistance Independent of Obesity by Reducing GIP Responses
High intakes of carbohydrates, particularly sucrose, in Western societies are associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related to the carbohydrate quantity or the hormonal responses, particularly Glucose-dependent Insuli...
ORGANISM(S): Mus musculus 
2014-12-05 | E-GEOD-54723 | biostudies-arrayexpress
TranscriptomicsCigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS). COPD pathogenesis is initiated and perpetuated by an abnormal CS-induced inflammatory response of the lungs, involving both...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-52509 | biostudies-arrayexpress
TranscriptomicsFunctional dissection of the Paired domain of Pax6 – distinct roles of subdomains in neurogenesis and proliferation
The transcription factor Pax6 acts as a key developmental regulator in various organs. In the developing brain Pax6 regulates patterning, neurogenesis and proliferation, but how these diverse effects are mediated at the molecular level is not well understood. As Pax6 regulates forebrain development ...
ORGANISM(S): Mus musculus 
2013-03-19 | E-GEOD-35260 | biostudies-arrayexpress
TranscriptomicsTRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate
Evolution of the mammalian brain encompassed a remarkable increase in size of cerebral cortex, including tangential and radial expansion, but the mechanisms underlying these key parameters are still largely unknown. Here, we identified the novel DNA associated protein TRNP1 as a regulator of cerebra...
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-40582 | biostudies-arrayexpress
TranscriptomicsCytokines dominate the secretome of primary human myotubes in an in vitro exercise model
Muscle contraction during exercise is the major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the benefical adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes ...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-44051 | biostudies-arrayexpress
TranscriptomicsThe transcriptome of prospectively isolated adult neural stem cells
Since the discovery of adult neural stem cells, their exact identity is still under discussion. Moreover, the lack of a reproducible procedure to purify neural stem cells prospectively rather than by growing them in vitro has so far precluded their study at the transcriptome level. Here we demonstra...
ORGANISM(S): Mus musculus 
2010-11-19 | E-GEOD-18765 | biostudies-arrayexpress
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