TRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate

ABSTRACT: Evolution of the mammalian brain encompassed a remarkable increase in size of cerebral cortex, including tangential and radial expansion, but the mechanisms underlying these key parameters are still largely unknown. Here, we identified the novel DNA associated protein TRNP1 as a regulator of cerebral cortical expansion in both these dimensions. Gain and loss of function experiments in the mouse cerebral cortex in vivo demonstrate that high Trnp1 levels promote neural stem cell self-renewal and tangential expansion, while lower levels promote radial expansion resulting in a potent increase in the generation of intermediate progenitors and outer radial glial cells resulting in folding of the otherwise smooth murine cerebral cortex. Remarkably, TRNP1 expression levels exhibit regional differe

ORGANISM(S): Mus musculus

SUBMITTER: Magdalena Goetz 

PROVIDER: E-GEOD-40582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress