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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
MetabolomicsSpermine is an endogenous iron chelator that inhibits ferroptosis

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. Here, we identify spermine—a polyamine derived from spermidine—as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing, and biophysical studies of the in...

2025-11-11 | MTBLS13306 | MetaboLights
TranscriptomicsTranscription profiling of rat duodenal samples at different developmental stages and the effects of iron-deficiency
The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages.
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1892 | biostudies-arrayexpress
TranscriptomicsNeisseria gonorrhoeae FA1090 transcriptional response to iron availability
4 pan-Neisseria arrays examining the gonococcal response to iron availability. Dual channel (Cy3/Cy5) arrays, using random nonamers for cDNA generation. Arrays scanned with ScanArray ExpressHT microarray scanner. Data analyzed using ArrayVision 7.0 and compiled in GeneSpring.
ORGANISM(S): Neisseria gonorrhoeae 
2010-06-09 | E-GEOD-2147 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of the human malaria parasite Plasmodium falciparum 3D7 cultured under different iron conditions
Background: Host iron deficiency is protective against severe malaria as the human malaria parasite Plasmodium falciparum depends on free iron from its host to proliferate. Due to the absence of transferrin, ferritin, ferroportin, and a functional heme oxygenase, the parasite’s essential pathways of...
ORGANISM(S): Plasmodium falciparum 
2024-04-08 | E-MTAB-13411 | biostudies-arrayexpress
TranscriptomicsTranscriptional Response to Iron Limitation in Pelagibacter ubique
We investigated the gene expression responses of Candidatus Pelagibacter ubique cultures to iron limitation. Differential expression was observed for genes in iron acquisition and incorporation operons. SfuC in particular was 16 times higher in iron-limited cultures and encodes a periplasmic iron-bi...
ORGANISM(S): Candidatus Pelagibacter ubique HTCC1062 
2010-05-05 | E-GEOD-20962 | biostudies-arrayexpress
TranscriptomicsExpression analysis of the response to wild-type and pye-1 mutants to iron sufficient or iron deficient conditions
Transcriptional profile of whole roots of wild-type and pye-1 mutants exposed to 24 hours -Fe were generated Global population increases and climate change underscore the need for better comprehension of how plants acquire and process nutrients such as iron. A systems biology approach was taken to e...
ORGANISM(S): Arabidopsis thaliana 
2010-10-12 | E-GEOD-21443 | biostudies-arrayexpress
TranscriptomicsmRNA composition of IRP1 mRNPs in mouse tissues
Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation with IRP1 (iron regulatory protein 1). Reference Sanchez at al., 2007 Nat. Protoc. Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation ...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-17096 | biostudies-arrayexpress
TranscriptomicsmRNA composition of IRP2 mRNPs in mouse tissues
Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation with IRP2 (iron regulatory protein 2). Reference Sanchez at al., 2007 Nat. Protoc. Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation ...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-17097 | biostudies-arrayexpress
TranscriptomicsLiver miRNA profiling in iron deficient and overload mice
8-week-old wild-type 129S6/SvEvTac mice were maintained under regular iron diet (containing 330 ppm iron) or iron-enriched diet (the same standard diet supplemented with 2% carbonyl iron) for 4 weeks. 7-week-old wild-type 129S6/SvEvTac mice were maintained under iron-deficient diet (with negligible ...
ORGANISM(S): Mus musculus 
2014-09-04 | E-MTAB-1520 | biostudies-arrayexpress
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