Toxoplasma uses metal nutrients like iron and copper for vital functions in their energy metabolism. Here, we have used stable isotope labelling to track the incorporation of glucose and glutamine into metabolic pathways, primarily focusing on central carbon metabolism, when these metals are disr...

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. Here, we identify spermine—a polyamine derived from spermidine—as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing, and biophysical studies of the in...

GBM displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in glioma remains incompletely understood. DFO, an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of a...