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MetabolomicsSpermine is an endogenous iron chelator that inhibits ferroptosis

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. Here, we identify spermine—a polyamine derived from spermidine—as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing, and biophysical studies of the in...

2025-11-11 | MTBLS13306 | MetaboLights
MetabolomicsHierarchical Carbon Metabolism in Iron-Deficient Bacteria Favors Iron-Scavenging Strategy

High-affinity iron (Fe) scavenging compounds, or siderophores, are widely employed by soil bacteria to survive scarcity in bioavailable Fe. Siderophore biosynthesis relies on cellular carbon metabolism, despite reported decrease in both carbon uptake and Fe-containing metabolic proteins in Fe-def...

2020-12-05 | MTBLS1715 | MetaboLights
MetabolomicsAromatic amino acids metabolism shapes autophagy mediated adaptation to iron deprivation in glioma

GBM displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in glioma remains incompletely understood. DFO, an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of a...

2026-08-20 | MTBLS15394 | MetaboLights
TranscriptomicsFunctional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI
Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitat...
ORGANISM(S): Proteus mirabilis HI4320 
2010-09-09 | E-GEOD-18051 | biostudies-arrayexpress
TranscriptomicsExpression analysis of 6 serotypes of Actinobacillus pleuropneumonia during iron deprivation
Investigation of whole genome changes in six serotypes of Actinobacillus pleuropneumoniae in control cultures compared to bacteria grown in media containg the iron chelator 2,2'-dipyridyl. A 48 chip study using total RNA recovered from four different control cultures and four different iron depleted...
ORGANISM(S): Actinobacillus pleuropneumoniae serovar 2 str. 4226 
2010-10-01 | E-GEOD-24470 | biostudies-arrayexpress
GenomicsIron-sensitive RNA regulation by poly C binding proteins [chelator]
Iron-sensitive RNA regulation by poly C binding proteins [chelator]
PRJNA1175600 | ENA
TranscriptomicsGlobal gene expression analysis of the phytopathogen Xylella fastidiosa at low iron availability
Xylella fastidiosa is the etiologic agent of a wide range of plant diseases including citrus variegated chlorosis (CVC), a major threat to the Brazilian citrus industry. Genome sequences of several strains of this phytopathogen are accessible, enabling large-scale functional studies. Transcript leve...
ORGANISM(S): Xylella fastidiosa 
2007-08-31 | E-GEOD-5888 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of the phytopathogen Xylella fastidiosa at high iron availability
Xylella fastidiosa is the etiologic agent of a wide range of plant diseases including citrus variegated chlorosis (CVC), a major threat to the Brazilian citrus industry. Genome sequences of several strains of this phytopathogen are accessible, enabling large-scale functional studies. Transcript leve...
ORGANISM(S): Xylella fastidiosa 
2007-09-01 | E-GEOD-5886 | biostudies-arrayexpress
ProteomicsProteomic analyses of iron deprived NK92 cells with deferoxamine or PPMX-T003
This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody)...
ORGANISM(S): Homo Sapiens (human) 
2025-07-04 | PXD059223 | JPOST Repository
GenomicsTreatment of a human lymphoblastoid cell line with the iron chelator deferoxamine
Treatment of a human lymphoblastoid cell line with the iron chelator deferoxamine
PRJNA818298 | ENA
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