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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
ClinicalIron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate.
The main objective of this study is to evaluate the efficacy of intravenous iron sucrose in increasing preoperative haemoglobin values in patients with colo-rectal neoplasm and iron deficiency anemia, compared to the standard treatment with oral iron. It will also determine whether intravenous iron ...
2019445 | ecrin-mdr-crc
GenomicsCardiac transcriptome in iron-deficiency anemia
Cardiac transcriptome in iron-deficiency anemia
PRJNA682047 | ENA
TranscriptomicsTranscription profiling of peripheral blood lymphocytes (PBL) from four pediatric renal allograft recipients with acute rejection and concurrent anemia
Compromised renal function after renal allograft transplantation often results in anemia in the recipient. Molecular mechanisms leading to anemia during acute rejection are not fully understood; inadequate erythropoietin production and iron deficiency have been reported to be the main contributors. ...
ORGANISM(S): Homo sapiens 
2005-11-01 | E-SMDB-2730 | biostudies-arrayexpress
ClinicalUsefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT)
Prospective study to test whether the immunochemical fecal occult blood test (FIT) for colorectal cancer (CRC) helps to prioritize patients with iron deficiency anemia for colonoscopy.
2216665 | ecrin-mdr-crc
TranscriptomicsTranscription profiling of livers from 74-day old male rats fed vitamin A sufficient or vitamin A deficient diet for 53 days
Analysis of livers from 74-day old male rats fed vitamin A sufficient or vitamin A deficient diet for 53 days. Either 10ug or 2ug of total RNA used in standard Affymetrix protocol
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1600 | biostudies-arrayexpress
ProteomicsMultiomic Profiling of Iron Deficient Infant Monkeys Reveals Alterations in Neurologically Important Biochemicals in Serum and CSF Prior to the Onset of Anemia
Background: The effects of iron deficiency anemia (IDA) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, biomarkers of iron-dependent brain health are lacking in humans. Prior analyses in rhesus in...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2022-03-18 | PXD028275 | Pride
Infancy Lc-msms Proteomics Acute phase Metabolomics Monkey Tmt Serum Csf Neurological function Iron deficiency anemia Synaptogenesis 
TranscriptomicsA strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice
Tmprss6 is the master inhibitor of hepcidin and its inactivation causes iron refractory iron deficiency anemia both in human and in mice. Mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficienct-high hepcidin Tmprss6 null mice. We invest...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-46287 | biostudies-arrayexpress
UnknownScreening for Anemia and Iron Deficiency in the Adult Portuguese Population.
Not available
S-EPMC7411453 | biostudies-literature
ClinicalIntravenous Ferric Carboxymaltose vs. Oral Iron Substitution in Patients With Metastatic Colorectal Cancer (CRC) and Iron Deficiency Anemia: a Randomized Multicenter Treatment Optimization Study.
Iron deficiency has a high prevalence in colorectal cancer patients ranging at ca. 60%. About 70% of these patients suffer from iron deficiency anemia (IDA) which adds both physical and cognitive impediments to an already straining chemotherapy. Moreover, a chronic disease like cancer often results ...
2191960 | ecrin-mdr-crc
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