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MetabolomicsHierarchical Carbon Metabolism in Iron-Deficient Bacteria Favors Iron-Scavenging Strategy

High-affinity iron (Fe) scavenging compounds, or siderophores, are widely employed by soil bacteria to survive scarcity in bioavailable Fe. Siderophore biosynthesis relies on cellular carbon metabolism, despite reported decrease in both carbon uptake and Fe-containing metabolic proteins in Fe-def...

2020-12-05 | MTBLS1715 | MetaboLights
MetabolomicsToxoplasma gondii metabolic flexibility in response to iron deprivation

Iron is an essential nutrient for many critical cellular processes. As a consequence of diverse and dynamic host environments, the obligate intracellular parasite Toxoplasma gondii must adapt to iron limited conditions. To investigate the adaptations critical to parasite survival under these cond...

2026-03-18 | MTBLS12831 | MetaboLights
Proteomics,MultiomicsTranscriptional and translational regulatory responses to iron limitation in the globally distributed marine bacterium Candidatus Pelagibacter ubique
Investigation of the gene expression responses of Candidatus Pelagibacter ubique cultures to iron limitation in natural seawater media supplemented with a siderophore to chelate iron. Quantitative peptide mass spectrometry revealed that sfuC protein abundance increased 27-fold, despite an average de...
ORGANISM(S): Candidatus Pelagibacter Ubique (ncbitaxon:198252) 
2020-05-18 | MSV000085445 | MassIVE
TranscriptomicsTranscriptional Response to Iron Limitation in Pelagibacter ubique
We investigated the gene expression responses of Candidatus Pelagibacter ubique cultures to iron limitation. Differential expression was observed for genes in iron acquisition and incorporation operons. SfuC in particular was 16 times higher in iron-limited cultures and encodes a periplasmic iron-bi...
ORGANISM(S): Candidatus Pelagibacter ubique HTCC1062 
2010-05-05 | E-GEOD-20962 | biostudies-arrayexpress
TranscriptomicsBordetella bronchiseptica RB50 iron limitation 2
Bordetella bronchiseptica RB50 was shifted from iron replete to either iron depleted or iron replete media, and samples were taken post shift for transcriptional profiling
ORGANISM(S): Bordetella bronchiseptica 
2011-09-08 | E-MEXP-3076 | biostudies-arrayexpress
TranscriptomicsBordetella pertussis Tohama I iron limitation 1
B. pertussis Tohama I was grown in iron-depleted or iron-replete media and sampled at several time points to assess global gene expression
ORGANISM(S): Bordetella pertussis 
2011-09-08 | E-MEXP-3263 | biostudies-arrayexpress
TranscriptomicsDifferential expression of genes in the WT and hupB KO strain of Mycobacterium tuberculosis H37Rv upon iron limitation
HupB is a 28 kDa in Mycobacterium tuberculosis that is co-expressed with the siderophores mycobactin and carboxymycobactin upon iron limitation. High levels of all the three components are seen in low iron (LI; 0.02 M-BM-5g Fe / mL) organisms, with negligible expression in high iron organisms (HI; 8...
ORGANISM(S): Mycobacterium tuberculosis 
2014-03-18 | E-GEOD-53254 | biostudies-arrayexpress
TranscriptomicsFunctional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI
Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitat...
ORGANISM(S): Proteus mirabilis HI4320 
2010-09-09 | E-GEOD-18051 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of Acinetobacter baumannii ATCC 17978 to limiting iron availability
A. baumannii ATCC 17978 cells were incubated under iron replete (mueller-hinton) and iron limiting (MH + 200 µM 2,2'-dipyridyl) conditions, total RNA was extracted when cultures reached OD600=0.7. The probes on the microarray cover all predicted open reading frames (at least 4 per ORF) and addition...
ORGANISM(S): Acinetobacter baumannii 
2013-10-18 | E-GEOD-24921 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of the marine pennate diatom Phaeodactylum tricornutum to Fe limitation
Diatoms, which are responsible for up to 40% of the 45 to 50 billion metric tons of organic carbon production each year in the sea, are particularly sensitive to Fe stress. Here we describe the transcriptional response of the pennate diatom Phaeodactylum tricornutum to Fe limitation using a partial ...
ORGANISM(S): Phaeodactylum tricornutum 
2010-05-27 | E-GEOD-8675 | biostudies-arrayexpress
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