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MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
TranscriptomicsTranscription profiling of liver from wild type and Hfe-/- mice with hereditary hemochromatosis subjected to dietary iron overload and treatment with nifedipine to reverse iron overload
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues leading to eventual organ failure. We have discovered a novel mechanism to reverse iron overload by pharmacological modulation of the dival...
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-982 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse duodenum and liver with primary (Hfe ?/? and C282Y homozygous mice) and secondary iron overload vs 129S6/SvEvTac wild type controls
We determined duodenal and liver gene response patterns in mice with primary (Hfe ?/? and C282Y homozygous mice) and secondary iron overload versus 129S6/SvEvTac wild type controls.
ORGANISM(S): Mus musculus 
2013-01-30 | E-MEXP-5 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CaCo-2 cells following various iron treatments
We investigated transcriptional response of CaCo-2 cells to iron treatments, we studied hemin effect by adding hemin to DMEM-FBS medium and iron deficiency effects in using an iron free medium compared to the same supplemented with FAC (ferric ammonium citrate). Experiment Overall Design: Biologica...
ORGANISM(S): Homo sapiens 
2008-01-19 | E-GEOD-3573 | biostudies-arrayexpress
ProteomicsIron Toxicity targeting mitochondrial Iron-Sulfur cluster enzymes
Unregulated nutritional iron absorption in hereditary hemochromatosis causes its overload, especially in liver. While this may lead to severe pathology, intriguingly, it may also frequently go unrecognized. Indeed, profound iron loading in hemochromatosis Hfe knockout mice and hemochromatosis Huh7 h...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD070837 | Pride
Iron-sulfur cluster enzymes Mitochondria Hemochromatosis Trace metals Methanobactin Liver Iron overload 
TranscriptomicsRat Pancreatic Tissue From Animals Fed Either an Iron Deficient or Iron Loaded vs. Iron Adequate Diet
Microarray analysis of pancreatic tissue comparing gene expression in rats fed an iron deficient or iron loaded diet vs. iron adequate diet. Goal was to determine changes in gene expression in response to iron status. 2 separate two-condition experiments: iron deficient (FeD) vs. iron adequate (FeA)...
ORGANISM(S): Rattus norvegicus 
2013-02-27 | E-GEOD-44699 | biostudies-arrayexpress
GenomicsDendritic cell iron overload exacerbates acetaminophen hepatotoxicity
Dendritic cell iron overload exacerbates acetaminophen hepatotoxicity
PRJNA1198320 | ENA
TranscriptomicsA Liver Hepcidin-Intestinal HIF-2α Axis Regulates Iron Absorption During Systemic Iron Deficiency, Hypoxia and Hemochromatosis
Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin (Hamp), a hepatic-derived hormone that controls iron mobilization through its molecular target, ferroportin (FPN), the only known mammalian iron exporter. Here, we took a transcriptomi...
ORGANISM(S): Mus musculus 
2018-12-12 | E-MTAB-7329 | biostudies-arrayexpress
ModelsMitchell2013 - Liver Iron Metabolism
Mitchell2013 - Liver Iron Metabolism The model includes the core regulatory components of human liver iron metabolism. This model is described in the article: A computational model of liver iron metabolism. Mi...
2024-09-02 | BIOMD0000000498 | BioModels
ProteomicsFerroptosis inhibition by oleic acid mitigates iron-overload-induced injury.
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the context of iron-overload-mediated damage. Exogenous oleic aci...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045642 | Pride
C. elegans Oleic acid ferroptosi 
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