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ProteomicsIron Toxicity targeting mitochondrial Iron-Sulfur cluster enzymes
Unregulated nutritional iron absorption in hereditary hemochromatosis causes its overload, especially in liver. While this may lead to severe pathology, intriguingly, it may also frequently go unrecognized. Indeed, profound iron loading in hemochromatosis Hfe knockout mice and hemochromatosis Huh7 h...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD070837 | Pride
Iron-sulfur cluster enzymes Mitochondria Hemochromatosis Trace metals Methanobactin Liver Iron overload 
UnknownDNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.
Not available
S-EPMC3378879 | biostudies-literature
TranscriptomicsIron uptake experiments in yeast
The budding yeast S. cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron. Here we have studied the transcriptional response to iron deprivation, and have identified ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-07 | E-GEOD-4196 | biostudies-arrayexpress
UnknownBoth human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
Not available
S-EPMC3546607 | biostudies-literature
UnknownStructural diversity of cysteine desulfurases involved in iron-sulfur cluster biosynthesis.
Not available
S-EPMC8918507 | biostudies-literature
UnknownMechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich's ataxia.
Not available
S-EPMC6556584 | biostudies-literature
UnknownDysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.
Not available
S-EPMC4042101 | biostudies-literature
UnknownExpanding the phenotypic and molecular spectrum of NFS1-related disorders that cause functional deficiencies in mitochondrial and cytosolic iron-sulfur cluster containing enzymes.
Not available
S-EPMC8863643 | biostudies-literature
UnknownDestruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase.
Not available
S-EPMC5941298 | biostudies-literature
UnknownIron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.
Not available
S-EPMC3530001 | biostudies-literature
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