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MetabolomicsCalenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in a type 2 diabetes model Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in cell, organ-on-a-chip, and mouse models of type 2 diabetes.

Glibenclamide (GLIB), a type 2 diabetes therapy, has long-term safety concerns. Probiotic–drug coadministration, an emerging adjunctive approach for metabolic diseases, improves therapeutic outcomes and side effects. Here, Bifidobacterium animalis B960 was selected from 71 probiotic strains by HP...

2025-07-08 | MTBLS12697 | MetaboLights
ProteomicsQuantitative proteomics in G1 cells reveals the insulin receptor adaptor IRS2 as an APC/CCdh1 substrate
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls progression through the eukaryotic cell cycle by targeting key substrates for degradation through the ubiquitin proteasome pathway. During G1, the APC/C works in concert with its co-activator Cdh1 to recognize and u...
ORGANISM(S): Homo sapiens (Human) 
2020-06-22 | PXD018329 | Pride
Tmt Human Irs2 Apc substrate 
TranscriptomicsEffects of sodium tungstate administration in Irs2 -/- mice
Relative beta cell deficit and increased beta cell apoptosis are hallmarks of type 2 diabetes (T2D). The Insulin/Insulin Growth Factor (Igf) signaling pathway is an established regulator of beta cell survival and is found downregulated in human T2D islets. The Insulin Receptor Substrate 2 (Irs2) pla...
ORGANISM(S): Mus musculus 
2014-01-19 | E-GEOD-43620 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver cells with liver specific deletion of Irs1 and/or Irs2 and Foxo1during fasting and feeding
The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon gene expression in the fasted and fed liver of mice; and the effect of liver specific Foxo1 deletion in the Irs1 and Irs2 knockout liver during fasting and feeding.
ORGANISM(S): Mus musculus 
2008-07-31 | E-MEXP-1649 | biostudies-arrayexpress
GenomicsIRS2 Promotes Proliferation and Drives Invasion-Migration in SI-NETs.
IRS2 Promotes Proliferation and Drives Invasion-Migration in SI-NETs.
PRJNA1310538 | ENA
GenomicsGenomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
PRJNA838019 | ENA
TranscriptomicsIRS2 Promotes Proliferation and Drives Invasion-Migration in SI-NETs.
I investigated the role of insulin receptor substrate 2 (IRS2) in small-intestinal neuroendocrine tumours (SI-NETs). Using SI-NET cell lines (STC-1 and Glu-tag), I found that IRS2 was significantly upregulated. IRS2 knockdown inhibited cellular proliferation, migration, and invasion, while its overe...
ORGANISM(S): Mus musculus 
2025-08-26 | GSE306367 | GEO
TranscriptomicsEffects of sodium tungstate administration in Irs2 -/- mice
Relative beta cell deficit and increased beta cell apoptosis are hallmarks of type 2 diabetes (T2D). The Insulin/Insulin Growth Factor (Igf) signaling pathway is an established regulator of beta cell survival and is found downregulated in human T2D islets. The Insulin Receptor Substrate 2 (Irs2) pla...
ORGANISM(S): Mus musculus 
2014-01-19 | GSE43620 | GEO
GenomicsEndothelial TFEB improves glucose intolerance via upregulation of IRS1 and IRS2
Endothelial TFEB improves glucose intolerance via upregulation of IRS1 and IRS2
PRJNA622861 | ENA
TranscriptomicsGenomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
Colorectal cancer (CRC) is currently the fourth leading etiology of brain metastasis (BM). Yet, mechanisms supporting the formation of CRC BM are mostly unknown. In order to identify drivers that lead to tropism and adaptation of CRC cells to the brain environment, we analyzed an extensive genomic d...
ORGANISM(S): Homo sapiens 
2022-05-16 | GSE203017 | GEO
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