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TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers [Expression analysis]
Embryogenesis is tightly regulated by multiple levels of epigenetic systems such as DNA methylation, histone modification, and chromatin remodeling. DNA methylation patterns are erased in primordial germ cells and in the interval immediately following fertilization. Subsequent reprogramming occurs...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32081 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers
This SuperSeries is composed of the following subset Series: GSE32080: DNA methylation profiling of embryonic stem cell differentiation into the three germ layers [MeDIP analysis] GSE32081: DNA methylation profiling of embryonic stem cell differentiation into the three germ layers [Expression analys...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32082 | biostudies-arrayexpress
TranscriptomicsGenome wide analysis of gene expression in LPS stimulated splenic B cell.
Analysis of class switch recombination, maturation or differenciation of B cells at gene expression levels. The hypothesis tested in the present study was that TLR signaling in B cells plays an pivotal role for class switch, maturation and differenciation. Total RNA obtained from cultured splenic B ...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-57837 | biostudies-arrayexpress
TranscriptomicsStepwise development of hematopoietic stem cells from embryonic stem cells
The cellular ontogeny of hematopoietic stem cells (HSCs) remains poorly understood because their isolation from and their identification in early developing small embryos are difficult. We attempted to dissect early developmental stages of HSCs using an in vitro mouse embryonic stem cell (ESC) diffe...
ORGANISM(S): Mus musculus 
2009-03-18 | E-GEOD-15053 | biostudies-arrayexpress
TranscriptomicsGene repression with H3K27me3 modification in human small cell lung cancer
Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis due to early dissemination and rapid growth. We here analyze gene expression profile of 23 clinical SCLC samples. EZH2 was found to be highly expressed in SCLC samples compared to 42 normal tissues including the normal lun...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-43346 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers [MeDIP analysis]
Embryogenesis is tightly regulated by multiple levels of epigenetic systems such as DNA methylation, histone modification, and chromatin remodeling. DNA methylation patterns are erased in primordial germ cells and in the interval immediately following fertilization. Subsequent reprogramming occurs...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32080 | biostudies-arrayexpress
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