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MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
MetabolomicsMetabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of ...
2021-11-09 | MTBLS1041 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
TranscriptomicsComprehensive gene expression analysis of cerebral cortices from mature rats after neonatal hypoxic-ischemic brain injury
Neonatal hypoxic-ischemic (HI) encephalopathy can lead to severe brain damage and is a common cause of neurological handicaps in adulthood. To elucidate the molecular events occurring in cerebral cortices of mature rats (8 weeks old) after neonatal HI brain insult, we performed comprehensive gene ex...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-37777 | biostudies-arrayexpress
GenomicsYthdf3 Knockdown Protects Against Hypoxic-Ischemic Cortical Neuron Injury by Wwtr1
Ythdf3 Knockdown Protects Against Hypoxic-Ischemic Cortical Neuron Injury by Wwtr1
PRJNA1480735 | ENA
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
ProteomicsQuieting the Storm: Hypoxia as a Strategy to Boost UC-MSC Therapies for Hypoxic-Ischemic Brain Lesions in Neonatal Rats
Integrating stem cell therapies into clinical settings faces several challenges, particularly in achieving the high cell yields necessary for attaining therapeutic doses. Preconditioning with hypoxic conditions has shown promise in enhancing the mesenchymal stem cells (MSCs)’ reparative capabilities...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD060639 | Pride
Mesenchymal stem cell  brain hypoxia  cell therapy  hypoxic ischemic encephalopathy  preconditioning  proteomics 
GenomicsEarly brain microRNA and mRNA expression profiles after neonatal hypoxic-ischemic injury in a mouse model [NanoString]
Early brain microRNA and mRNA expression profiles after neonatal hypoxic-ischemic injury in a mouse model [NanoString]
PRJNA767347 | ENA
GenomicsTranscriptional signature of hypoxic preconditioning in a mouse model of ischemic acute kidney injury
Transcriptional signature of hypoxic preconditioning in a mouse model of ischemic acute kidney injury
PRJNA658148 | ENA
ProteomicsPeptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage
Hypoxic-ischemic brain injury (HIBD) causes neonatal death and serious neurological disability; however, there are currently no promising therapies for it excepting cooling. Therefore, in this study, we used peptidome analysis to identify differentially expressed peptides in cerebrospinal fluid (CS...
ORGANISM(S): Homo Sapiens 
2020-03-01 | PXD017797 |
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