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The connective tissue diseases (CTDs) are group of inflammatory disorders with overlapping clinical and serological manifestations. We have undertaken Lupus Extended Phenotype (LEAP) study in of a cohort of adult patients with CTDs, namely systemic lupus erythematosus, Sjogren's syndrome, mixed and ...
ORGANISM(S): Homo sapiens 
Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecul...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012274 | Pride
Role of PML in ISG induction in primary postnatal sympathetic neurons
ISG induction in ∆7bp IFNAR2 mutant, IFNAR1 KO and wild type THP1.
ISG induction differs immunogenical human splenic cDC2 activation from homeostatic ones
A previous study has shown that PML-dependent recruitment of HIRA to ISG promoters contributes to the up-regulation of gene expression as a result of cytokine release in response to HSV infection (McFarlane et al., 2019). Although carried out in non-neuronal cells, this study and others (Ulbricht et...
ORGANISM(S): Mus musculus 
2021-06-21 | GSE166738 | GEO
Two ISREs functioning cooperatively regulate ISG expression in West Nile virus infected IFNAR-/- MEFs
ISG 15 is associated with cervical cancer development
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