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Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system involving differentiation and massive cell fusion. Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in seve...
ORGANISM(S): Homo sapiens 
We have applied a recently developed, highly accurate and sensitive single-cell RNA-seq method (STRT/C1) to perform a molecular census of two regions of the mouse cerebral cortex: the somatosensory cortex and hippocampus CA1. We isolated cells fresh from somatosensory cortex (S1) and hippocampus CA1...
ORGANISM(S): Mus musculus 
Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental factors. Both variants of autoimmune susceptibility genes and environment are involved in the generation of aberrant epigenetic profiles in a cell-sp...
ORGANISM(S): Homo sapiens 
Third instar larval eye discs provide an in vivo model for cell cycle exit studies. Posterior to the Second Mitotic Wave proliferation is absent in a wild type eye disc. Inactivating mutations in tumor suppressor-like genes can lead to genome wide changes in gene expression that allow for inapprop...
ORGANISM(S): Drosophila melanogaster 
We used microarrays to identify genes that are differentially expressed in the absence of miR-998 expression. Drosophila third instar larvae were selected for RNA extraction and hybridization on Affymetrix microarrays. Three biological replicates for each genotype were prepared. The data was normali...
ORGANISM(S): Drosophila melanogaster 
Basal gene expression of T47D-MTVL human breast cancer cells growing in normal conditions Breast cancer cells T47D-MTVL cells were grown in rich media and total RNA was extracted to monitor basal gene expression
ORGANISM(S): Homo sapiens 
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