Islets - OmicsDI

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Unknown (4008)
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Clinical (2)

Organisms

Mus musculus (871)
Homo sapiens (749)
Rattus norvegicus (125)
Sus scrofa (6)
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Xenopus laevis (3)
mouse gut metagenome (3)
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Burkholderia pseudomallei K96243 (1)
Escherichia coli 8624 (1)
Vibrio cholerae O1 str. C6706 (1)
Salmonella enterica subsp. enterica (1)
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Cupriavidus metallidurans CH34 (1)
Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S (1)
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Organisms

Mus musculus (654)
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Danio rerio (8)
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Mus musculus musculus (2)
Macaca mulatta (2)
Ovis aries (2)
mouse gut metagenome (2)
Leptospira interrogans serovar Hebdomadis (1)
Rattus (1)
Mus sp. (1)
Mus (1)
Canis lupus familiaris (1)
Mus musculus domesticus (1)
unidentified (1)
synthetic construct (1)

Repository

ENA (1250)
geo (956)
biostudies-arrayexpress (732)
pride (111)
EGA (63)
MassIVE (26)
ExpressionAtlas (17)
BioModels (12)
MetaboLights (9)
jPOST (7)
iProX (6)
MetabolomicsWorkbench (5)
GNPS (3)
NODE (2)
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EVA (1)
GPMDB (1)
PAXDB (1)
PMR (1)

Tissue

Pancreatic islet (28)
Cell culture (23)
Pancreas (20)
Islet of Langerhans (20)
Pancreatic islet cell (11)
Type B pancreatic cell (5)
Pancreatic islet beta cell (4)
Epithelial cell (4)
B cell (4)
Liver (4)
Pancreas (3)
Endocrine pancreas (3)
Macrophage (3)
Fibroblast (3)
Primary cell (3)
Permanent cell line cell (3)
Blood (3)
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Beta-TC3 cell (2)
Alpha-TC1.6 cell (2)
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Cellular modified amino acid catabolic process (1)

Disease

Type 2 diabetes mellitus (19)
Type 1 diabetes mellitus (16)
Disease free (6)
Normal (5)
Diabetes (3)
Diabetes mellitus (2)
Pancreatic ductal adenocarcinoma (2)
Maturity-onset diabetes of the young type 1 (2)
4T1 tumor-bearing (1)
Aggressive insulitis (1)
Nondiabetic (1)
Perineural invasion (1)
Low-stage neuroblastoma (1)
Mild hyperglycemia (1)
Mild hyperglycemia, liver dysfunction, and renal glycosuria (1)
Chronic pancreatitis (1)
Pancreatic cancer (1)
Not Applicable (1)
Pancreatic adenocarcinoma (1)
Normal (1)
No disease (1)
Healthy donor tissue (1)
Adenocarcinoma (1)
Barrett's esophagus (1)
Colorectal Neoplasms (1)
Not Available (1)
Obesity (1)
Diabetes mellitus (1)
Insulinoma (1)
Pancreatic endocrine carcinoma (1)

Technology Type

Mass Spectrometry (116)
Shotgun proteomics (51)
Bottom-up proteomics (26)
Data-independent acquisition (14)
Data-dependent acquisition (12)
Top-down proteomics (12)
Affinity purification coupled with mass spectrometry proteomics (11)
Mass spectrometry assay (6)
Mass spectrometry (3)
ESI (3)
ILLUMINA, Illumina HiSeq 2500 (2)
Illumina HiSeq 2000 (2)
EI (2)
All-ion fragmentation (2)
SWATH MS (2)
SRM/MRM (2)
ILLUMINA, Illumina Genome Analyzer IIx, Illumina HiSeq 2500 (1)
Complete Genomics (COMPLETE_GENOMICS) (1)
DiaPASEF (1)

Instrument Platform

Illumina HiSeq 2000 (25)
Illumina HiSeq 2500 (20)
Illumina NovaSeq 6000 (18)
Illumina HiSeq 4000 (17)
NextSeq 500 (15)
Affymetrix Fluidics Station 400 (6)
G2500A Hewlett Packard (4)
Affymetrix GeneChip Scanner 3000 (GCS3000) (3)
Illumina Genome Analyzer IIx (3)
NextSeq 2000 (3)
Agilent DNA Microarray Scanner Model #G2565BA (2)
Illumina Genome Analyzer II (2)
Illumina HiSeq 1000 (2)
Illumina MiSeq (2)
Illumina HiSeq 3000 (2)
NuGEN Trio low input RNA-seq (1)
RNeasy Micro Kit (QIAGEN #74004) (1)
PALM Microbeam Rel. 4.9 with RoboMover microscope (Zeiss) (1)
All computation performed on the Vanderbilt ACCRE cluster. (1)
Microbeads (1)
GeneChip Instrument System (1)
Affymetrix mouse gene 1.0 ST arrays (1)
Qiagen MinElute (1)
Affymetrix GeneArray Scanner (1)
Affymetrix GeneChip Scanner 3000 7G (1)
Agilent 2100 Bioanalyzer (1)
Illumina Genome Analyzer (1)
GenePix 4000A [Axon Instruments] (1)
NanoDrop (1)
Scanning hardware (1)

Publication Date

2023 (156)
2014 (146)
2024 (132)
2022 (125)
2013 (122)
2025 (117)
2026 (117)
2021 (112)
2015 (107)
2020 (97)
2016 (93)
2012 (90)
2019 (85)
2010 (75)
2018 (55)
2011 (55)
2017 (53)
2008 (43)
2009 (38)
2007 (23)
2006 (16)
2005 (13)
2004 (3)
2003 (2)

UNIPROT ID/AC

P14618 (2)
P17858 (2)
P35557 (2)
O60825 (2)
Q16875 (2)
P16118 (2)
Q16877 (2)
P05062 (2)
P09972 (2)
P04075 (2)
P00338 (2)
P07195 (2)
Q9BYZ2 (2)
P07864 (2)
P30613 (2)
P06744 (2)
P09104 (2)
P13929 (2)
O00757 (2)
P08237 (2)
O14556 (2)
P00558 (2)
P07205 (2)
Q9NQ88 (1)
Q9UJ73 (1)
Q9UMQ9 (1)
Q9UMR0 (1)
Q01813 (1)
Q16850 (1)
Q9BQG2 (1)

CHEBI ID

CHEBI:16761 (5)
CHEBI:29108 (4)
CHEBI:14314 (4)
CHEBI:16905 (3)
CHEBI:4167 (3)
CHEBI:58579 (2)
CHEBI:16651 (2)
CHEBI:58289 (2)
CHEBI:58272 (2)
CHEBI:57604 (2)
CHEBI:58027 (2)
CHEBI:57642 (2)
CHEBI:57299 (2)
CHEBI:30616 (2)
CHEBI:61548 (2)
CHEBI:57540 (2)
CHEBI:57945 (2)
CHEBI:43474 (2)
CHEBI:456216 (2)
CHEBI:15377 (2)
CHEBI:15361 (2)
CHEBI:15422 (2)
CHEBI:16908 (2)
CHEBI:18021 (2)
CHEBI:3554 (1)
CHEBI:3338 (1)
CHEBI:3966 (1)
CHEBI:3312 (1)
CHEBI:3313 (1)
CHEBI:3628 (1)

Metabolite Name

Histidine (3)
Glycine (3)
Thymine (3)
Cholesterol (3)
Adenosine (3)
Threonine (3)
Synephrine (2)
O-phosphoethanolamine (2)
1,3-Diaminopropane (2)
Melezitose (2)
L-cystine (2)
1-methylhistamine (2)
Ribitol (2)
N6,N6,N6-Trimethyl-L-lysine (2)
Maslinic acid (2)
Norvaline (2)
Gly-Leu (2)
Glu-His (2)
2-aminoadipic acid (2)
Leucine (2)
Lactose (2)
EDTA (2)
Glycerol (2)
Glycine (2)
Trigonelline (2)
Uracil (2)
Valine (2)
Betaine (2)
Thiamine (2)
Diethanolamine (2)

First Public Date

2024 (150)
2023 (146)
2014 (129)
2025 (121)
2026 (120)
2022 (108)
2021 (106)
2020 (98)
2019 (80)
2017 (51)
2018 (49)
2015 (41)
2016 (32)
2013 (17)
2012 (1)
2010 (1)

Modelling Approach

Ordinary differential equation model (9)
Agent-based model (1)
Differential equation model (1)

Study status

Recruiting (1)
Completed (1)

Lab affiliation

Kubicek lab, Principal Investigator, Head of Molecular Discovery Platform, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (3)
Department of Fundamental Neurosciences, Rue du Bugnon 9, 1005, Lausanne (3)
Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway (3)
Department of Clinical Science, University of Bergen, Norway (2)
Proteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital (2)
University of Oxford (2)
Charles Perkins Centre, School of Medical Sciences, University of Sydney, Sydney, Australia. (2)
Medical Bioanalytics Institute for Ophthalmic Research Eberhard-Karls University of Tuebingen (2)
Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland (1)
Catholic University of Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium (1)
Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany (1)
Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 27402, United States; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 28081, United States (1)
Department of Cell and Regenerative Biology Department of Chemistry Director of Mass Spectrometry Human Proteomics Program University of Wisconsin-Madison (1)
Department of Biomedical Science, University of Copenhagen, Denmark (1)
Professor i molekylærbiologi og faglig leder av PROMEC Institutt for klinisk og molekylær medisin Fakultet for medisin og helsevitenskap geir.slupphaug@ntnu.no 72573076 91825455 Laboratoriesenteret, 231.05.034, Øya, Erling Skjalgssons g 1 (1)
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, Catholic University of Leuven (1)
Department of Fundamental Neurosciences University of Lausanne Rue du Bugnon 9 1005 Lausanne (1)
Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland (1)
University Ghent, VIB (1)
University of Colorado Denver Anschutz Medical Campus, Department of Pharmaceutical Sciences, Colorado, USA (1)
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Campusvej 55, Odense 5230 Denmark (1)
MRC-Laboratory of Medical Sciences (1)
Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Germany (1)
Washington University (1)
Department of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, (1)
Lab Head of Necker Proteomics Platform (1)
Department of Laboratory Medicine, Sahlgrenska academy, University of Gothenburg, Gothenburg, Sweden (1)
Paul & Ellen Lacy Professor of Pathology & Immunology Division of Immunobiology Washington University in St. Louis St. Louis, MO 63110 USA (1)
Washington University School of Medicine Department of Pathology & Immunology 425 S. Euclid, Campus Box 8118 St. Louis, MO 63110 (1)
Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy (1)

IsPrivate

False (12)

Model Flag

Non Kinetic (1)

Classification

bacteria (1)

Modification

56.026215 (1)
59.036279 (1)
-17.026549 (1)
42.010565 (1)
15.994915 (1)
Not available (1)

Study type

Transcription profiling by array (452)
RNA-seq of coding RNA (121)
ChIP-seq (27)
Comparative genomic hybridization by array (24)
Unknown experiment type (11)
Methylation profiling by high throughput sequencing (11)
RNA-seq of non coding RNA (10)
Methylation profiling by array (8)
MicroRNA profiling by array (7)
DNA-seq (7)
Animal - High-throughput sequencing (6)
Transcription profiling by RT-PCR (6)
ChIP-chip by tiling array (5)
ChIP-chip by array (5)
RNA-seq of total RNA (5)
RNA-seq of coding RNA from single cells (4)
ATAC-seq (3)
Other (3)
Cell line - High-throughput sequencing (2)
Genotyping by array (2)
MicroRNA profiling by high throughput sequencing (2)
Hi-C (2)
FAIRE-seq (1)
Transcription profiling by SAGE (1)
Animal - One-color microarray (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Bisulfite-seq (1)
4C (1)
Proteomic profiling by array (1)

Release Date

2022 (417)
2021 (363)
2020 (338)
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2018 (299)
2014 (279)
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2013 (227)
2012 (174)
2010 (165)
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2008 (91)
2026 (51)
2007 (51)
2006 (36)
2005 (14)
2004 (13)
2001 (7)
2003 (6)
1997 (6)
2000 (5)
1999 (3)
2002 (2)
1998 (2)

Location

Netherlands (1)
France (1)

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Metabolomic Profiles of Pancreatic β-Cells and Islets Exposed to Arsenic, Islets (part-II)

Not available

ORGANISM(S): Mus musculus

ST001314 | MetabolomicsWorkbench

Identification of HIPs in the islets of mice and non-diabetic human donors

Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2019-01-07 | PXD011606 | Pride

Hybrid insulin peptides (hips) Pancreatic islets

U13C Glucose Tracing of Young and Old Pancreatic Islets

Not available

ORGANISM(S): Mus musculus

ST000964 | MetabolomicsWorkbench

The Pdx1 Cistrome of Pancreatic Islets

We performed global location analysis of Pdx1 occupancy in mouse and human islets.

ORGANISM(S): Mus musculus

2012-05-23 | E-MTAB-1143 | biostudies-arrayexpress

Timecourse of U13C glucose labeling of pancreatic islets in young mice

Not available

ORGANISM(S): Mus musculus

ST000965 | MetabolomicsWorkbench

DNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes

Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...

ORGANISM(S): Homo sapiens

2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress

Identifying metabolite changes in human islets treated with Phospho-BAD mimicry and Inflammatory cytokines

Not available

ORGANISM(S): Homo sapiens

ST001953 | MetabolomicsWorkbench

Adiponectin improves local lipid metabolism in regenerating pancreatic islets after β-cell ablation

Pathways that stimulate β-cell regeneration remain of great clinical interest, yet effective therapeutic avenues that promote survival or reconstitution of β-cell mass remain elusive. Utilizing a mouse model with inducible β-cell apoptosis followed by adiponectin-mediated regeneration, we aimed to i...

ORGANISM(S): Mus musculus

2015-01-09 | E-GEOD-64787 | biostudies-arrayexpress

Proteomic profiles of Rat Pancreatic Islets

In this study, we achieved integrated transcriptomic and proteomic profiles of GK islets in a time-course fashion at different stages of T2D. Subsequent bioinformatics analysis revealed the chronological order of T2D-related molecular events during the deterioration of pancreatic islets. Our large q...

ORGANISM(S): Rattus norvegicus (Rat)

2017-06-02 | PXD004709 | Pride

Rat islets proteome

Metabolomic Profiles of Pancreatic β-Cells and Islets Exposed to Arsenic, part I β-Cells

Not available

ORGANISM(S): Mus musculus

ST001266 | MetabolomicsWorkbench

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