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TranscriptomicsInsert in CovS Gene Distinguishes a Pharyngeal and a Blood Isolate of Streptococcus pyogenes Found in the Same Individual.
Expression of the extensive arsenal of virulence factors by Streptococcus pyogenes are controlled by many regulators, of which covR/S is one of the best characterized and can influence ~15% of the genome. Animal models have established that mutants of CovR/S arise spontaneously in vivo resulting in ...
ORGANISM(S): Streptococcus pyogenes 
2010-05-01 | E-GEOD-21316 | biostudies-arrayexpress
TranscriptomicsComparison of the genome-sequenced variant of Campylobacter jejuni NCTC 11168 and the original clonal clinical isolate
This SuperSeries is composed of the following subset Series: GSE3953: Comparison of NCTC 11168 isolate vs. genome-sequenced variant, microaerobic and anaerobic conditions GSE3954: Genomotyping of 11168-GS vs. 11168-O Abstract: The genome sequence of the enteric bacterial pathogen Campylobacter jeju...
ORGANISM(S): Campylobacter jejuni 
2006-03-07 | E-GEOD-4387 | biostudies-arrayexpress
TranscriptomicsComparison of NCTC 11168 isolate vs. genome-sequenced variant, microaerobic and anaerobic conditions
Transcriptional analysis (RNA hybridization) for 11168-G (genome sequenced) vs. 11168-O (original), cultured microaerobically or anaerobically (published as "severely O2-limited). Published in Gaynor et al, J. Bacteriology 186:503-517 The genome sequence of the enteric bacterial pathogen Campy...
ORGANISM(S): Campylobacter jejuni 
2005-12-30 | E-GEOD-3953 | biostudies-arrayexpress
TranscriptomicsContribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata (part 1)
In this study, we aimed to determine genome-wide changes in gene expression driven by seven individual CgPDR1 hyperactive alleles as compared to wild-type allele to identify i) the CgPdr1p target genes differentially expressed in presence of CgPDR1 hyperactive alleles and ii) potential virulence fa...
ORGANISM(S): Candida glabrata 
2010-12-31 | E-GEOD-23827 | biostudies-arrayexpress
TranscriptomicsContribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates.
The capsular serotype has long been associated with the virulence of Streptococcus pneumoniae. Here we present an in-depth study of phenotypic and genetic differences between serotype 3 and serogroup 11 S. pneumoniae clinical isolates from both the general and indigenous populations of Australia. Bo...
ORGANISM(S): Streptococcus pneumoniae 
2011-12-01 | E-BUGS-126 | biostudies-arrayexpress
ModelsJenior2021 - Clostridium difficile 630 model
The pathogen Clostridioides difficile causes toxin-mediated diarrhea and is the leading cause of hospital-acquired infection in the United States. Due to growing antibiotic resistance and recurrent infection, targeting C. difficile metabolism presents a new approach to combat this infection. Genome-...
2023-11-27 | MODEL2205060002 | BioModels
FROG 
ProteomicsDifferential virulence of Aggregatibacter actinomycetemcomitans serotypes explained by exoproteome heterogeneity
Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative bacterial pathogen associated with periodontitis and non-oral diseases like rheumatoid arthritis and Alzheimer´s disease. Aa isolates with the serotypes a, b and c are globally most prevalent. Importantly, isolates displaying these seroty...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2022-12-16 | PXD036160 | Pride
Aggregatibacter actinomycetemcomitans Virulence Exoproteome Serotype Infection 
UnknownThe contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli.
Not available
S-EPMC3906297 | biostudies-literature
TranscriptomicsLoss of mitochondrial functions in Candida glabrata results in enhanced virulence in mice
Two C. glabrata related isolates recovered from the same patient undergoing azole therapy were characterized. The first isolate, BPY40, is azole-susceptibleand the second, BPY41, is azole-resistant. To determine whether the petite mutation conferred a selective advantage during host infection, the v...
ORGANISM(S): Candida glabrata 
2010-12-31 | E-GEOD-23826 | biostudies-arrayexpress
TranscriptomicsNovel virulence factors in host-adapted Pseudomonas aeruginosa infection of the Cystic Fibrosis airways
Pseudomonas aeruginosa airway infection is the primary cause of death in Cystic Fibrosis (CF). During early infection P. aeruginosa produces multiple virulence factors, which cause acute pulmonary disease and are largely regulated by quorum sensing (QS) intercellular signalling networks. Longitudina...
ORGANISM(S): Pseudomonas aeruginosa 
2010-11-04 | E-GEOD-25130 | biostudies-arrayexpress
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