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TranscriptomicsDownregulation of the Wnt antagonist Dkk2 links loss of Sept4 and myofibroblastic transformation of hepatic stellate cells
Background/Aims: Sept4, a subunit of the septin cytoskeleton specifically expressed in quiescent hepatic stellate cells (HSCs), is downregulated through transdifferentiation to fibrogenic and contractile myofibroblastic cells. Since Sept4?/? mice are prone to liver fibrosis, we examined the unknown ...
ORGANISM(S): Mus musculus 
2012-06-02 | E-GEOD-24588 | biostudies-arrayexpress
TranscriptomicsIdentification of Myt1 as a subunit of the neural cell type-specific LSD1 complex
Regulation of spatiotemporal gene expression in higher eukaryotic cells is critical for the precise and orderly development of undifferentiated progenitors into committed cell types of the adult. Recently, dynamic epigenomic regulation, including chromatin remodeling and histone modifications by tra...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-49685 | biostudies-arrayexpress
UnknownDeletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
Not available
S-EPMC5470042 | biostudies-literature
TranscriptomicsTranscription profile of adipose derived mesenchymal stem cells separated by cell surface protein N-cadherin.
Mesenchymal stem cells (MSCs) are one of most promising stem cell sources for regenerative medicine. MSCs have a differention ability into several tissues. However, their differentiation efficiency is considered quite limited. Especially, the differentiation efficiency into cardiomyocytes is very lo...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-35232 | biostudies-arrayexpress
GenomicsWhole-exome sequencing of Fanconi anemia
We performed whole-exome sequencing of two Fanconi anemia patients without mutation of known FA genes, and identified a novel FA gene FANCT.
EGAS00001001103 | EGA
TranscriptomicsIdentification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation
Chromosomes and genes are non-randomly arranged within the mammalian cell nucleus. Clustering of genes is of great significance in transcriptional regulation. However, the relevance of gene clustering in their expression during differentiation of neural precursor cells (NPCs) into astrocytes remains...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-66097 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of an RXR agonist HX630 regulated gene expression in murine pituitary corticotroph tumor cells (AtT20 cell)
To gain insight into the functional mechanisms of an RXR agonist HX630 in murine pituitary corticotroph tumor cells (AtT20 cell), especially concerning cell proliferation and apoptosis, we conducted whole genome microarray analysis to identify gene expression patterns, networks, and pathways in AtT2...
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-43783 | biostudies-arrayexpress
UnknownIPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus.
Not available
S-EPMC3888965 | biostudies-literature
GenomicsCopy number analysis of Diamond-Blackfan Anemia (DBA) using SNP array
Diamond–Blackfan anemia (DBA), is a rare congenital anemia that usually presents in infancy. About fifty percent of DBA patients possess mutations in ribosomal protains (RPs). In this study, we performed genomic copy number analysis using SNP arrays for 27 Japanese DBA patients to detect genomic c...
EGAS00000000105 | EGA
GenomicsDBA_250K - samples
DBA case samples using 250K Nsp
EGAD00010000096 | EGA
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