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UnknownA Phase 2, Prospective, Multicenter, Single-Arm Trial of Transarterial Chemoembolization Therapy in Combination Strategy with Lenvatinib in Patients with Unresectable Intermediate-Stage Hepatocellular Carcinoma: TACTICS-L Trial.
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S-EPMC10857829 | biostudies-literature
TranscriptomicsComparison of TEX and M9-ENL1 cell lines to HL60 and THP1 cell lines
Gene regulatory networks that govern hematopoietic stem cells (HSC) and leukemia–initiating cells (L-IC) are deeply entangled. Thus, the discovery of compounds that target L-IC while sparing HSC is an attractive but difficult endeavor. Presently, most drug discovery approaches fail to counter-screen...
ORGANISM(S): Homo sapiens 
2011-11-24 | E-GEOD-33892 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in rams experimentally infected with a rough virulent strain of Brucella ovis (acute phase)
The study demonstrated the gene expression through microarray analysis of total mRNA in rams experimentally infected with a rough (R) virulent strain of Brucella ovis in reproductive organs (epididymus, testicles, ampolae, vesicular glands, bulbourethral glands) and a pool of lymph nodes (inguinal a...
ORGANISM(S): Ovis aries 
2012-02-08 | E-GEOD-35612 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in rams experimentally infected with a rough virulent strain of Brucella ovis (chronic 1 phase)
The study demonstrated the gene expression through microarray analysis of total mRNA in rams experimentally infected with a rough (R) virulent strain of Brucella ovis in reproductive organs (epididymus, testicles, ampolae, vesicular glands, bulbourethral glands) and a pool of lymph nodes (inguinal a...
ORGANISM(S): Ovis aries 
2012-02-08 | E-GEOD-35613 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in rams experimentally infected with a rough virulent strain of Brucella ovis (chronic 2 phase)
The study demonstrated the gene expression through microarray analysis of total mRNA in rams experimentally infected with a rough (R) virulent strain of Brucella ovis in reproductive organs (epididymus, testicles, ampolae, vesicular glands, bulbourethral glands) and a pool of lymph nodes (inguinal a...
ORGANISM(S): Ovis aries 
2012-02-08 | E-GEOD-35614 | biostudies-arrayexpress
TranscriptomicsP493-6 treated with KJ-Pyr-9 and/or Doxycycline
In a fluorescence polarization screen for MYC-MAX interaction, we have identified a novel small molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. The Kd of KJ-Pyr-9 for MYC in vitro is 6.5 ± 1.0 nM as determined by backscattering interferometry; KJ-Pyr-9 also interferes with MYC-...
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-58168 | biostudies-arrayexpress
TranscriptomicsThe differentiation stage of p53- and Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development (part II)
We have previously reported that the deficiency of p53 alone or in combination with Rb (Rb-/- p53-/-) in adipose-derived MSCs (ASCs) promotes leiomyosarcoma-like tumors in vivo. Here, we hypothesized that the source of MSCs and/or the cell differentiation stage could determine the phenotype of sarco...
ORGANISM(S): Mus musculus 
2013-01-28 | E-GEOD-43803 | biostudies-arrayexpress
TranscriptomicsUnravelling the heterogeneity of haemogenic endothelium in human pluripotent stem cell differentiation cultures
In embryo, few Endothelial cells from Aorta would be producing Haemogenic endothelium (HE) cells. These HE cells would then be progressing to take kind of a round shape and Undergo EHT. They then take a full round shape to make Intra-aortic haematopoietic clusters (IAHC) cells. These IAHC cells woul...
ORGANISM(S): Homo sapiens 
2020-05-02 | E-MTAB-8271 | biostudies-arrayexpress
TranscriptomicsThe differentiation stage of p53- and Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development (part I)
We have previously reported that the deficiency of p53 alone or in combination with Rb (Rb-/- p53-/-) in adipose-derived MSCs (ASCs) promotes leiomyosarcoma-like tumors in vivo. Here, we hypothesized that the source of MSCs and/or the cell differentiation stage could determine the phenotype of sarco...
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-43781 | biostudies-arrayexpress
TranscriptomicsExpression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation
Although different sarcomas have been modeled in mice upon expression of fusion oncogenes in MSCs, sarcomagenesis has not been successfully modeled in human MSCs (hMSCs). We report that FUS-CHOP, a hallmark fusion gene in mixoid liposarcoma (MLS), has an instructive role in lineage commitment, and i...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48030 | biostudies-arrayexpress
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