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ProteomicsCo-IP protein identification of WT/MT IVNS1ABP in isogenic iPSCs derived NPCs
We identified a new disease characterized by severe neurological deficits in addition to progeria symptoms. It is caused by IVNSABP gene mutation. The association between IVNS1ABP and aging has never been reported before. By generating isogenic iPSCs from the patients’ fibroblasts and differentiatin...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD053645 | Pride
Ipscs Npcs Co-ip Ivns1abp 
TranscriptomicsEffect of IVNS1ABP mutation, knockout on gene expression during iPSCs differentiation to Neural Progenitors
A homozygous variant in IVNS1ABP was identified in three siblings, displaying progeroid features with severe neuropathy. The association between IVNS1ABP and aging has never been reported before. By generating isogenic iPSCs from the patients’ fibroblasts and differentiating the iPSCs into neural pr...
ORGANISM(S): Homo sapiens 
2026-01-23 | GSE270946 | GEO
GenomicsEffect of IVNS1ABP mutation, knockout on gene expression during iPSCs differentiation to Neural Progenitors
Effect of IVNS1ABP mutation, knockout on gene expression during iPSCs differentiation to Neural Progenitors
PRJNA1129086 | ENA
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