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GenomicsHomo sapiens isolate:J-Lat 10.6
RNA-seq analysis of TFD-treated J-Lat 10.6 cells
PRJNA1304135 | ENA
ProteomicsRBM39 organizes an m⁶A-dependent silencing complex to degrade Tat mRNA and maintain HIV-1 latency
Given the pivotal role of Tat in HIV-1 latency, we performed RNA pull-down assays in latently HIV-1-infected J-Lat 10.6 cells using biotinylated RNA probes (including a control RNA probe and a Tat-specific RNA probe) . Cell lysates were incubated with streptavidin agarose resin pre-bound to Tat RNA ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD064834 | Pride
Lc/ms Tat Rip J-lat 10.6 
GenomicsJ-Lat 10.6 cell line treated with either DMSO, 10μM compound 4, or 10μM compound 16 for 24 h.
J-Lat 10.6 cell line treated with either DMSO, 10μM compound 4, or 10μM compound 16 for 24 h.
PRJNA1294894 | ENA
UnknownEK-16A liposomes enhance HIV replication in ACH2 or J-Lat 10.6 cell engrafted NSG mice.
Not available
S-EPMC9194586 | biostudies-literature
TranscriptomicsJ-Lat 10.6 cell line treated with either DMSO, 10μM compound 4, or 10μM compound 16 for 24 h.
Human immunodeficiency virus (HIV) still remains a major global public health issue. Combination antiretroviral therapy (ART) is effective to reduce the morbidity and mortality of HIV infected patients. However, ART is unable to eradicate HIV due to the establishment of long-lived and proliferating ...
ORGANISM(S): Homo sapiens 
2026-01-14 | GSE303365 | GEO
Genomics
HIV-1 J-Lat 10.6 Nanopore MinION R9.4.1 and R10.3 sequencing
PRJNA812612 | ENA
OtherA modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
The goal of this CRISPR-based screen (Latency HIV-CRISPR) is to identify HIV-1 latency factors by evaluating multiple pathways simultaneously. Here are Illumina sequencing data and counts files from a Latency HIV-CRISPR screen using a custom guide RNA library targeting human epigenome genes (HuEpi)....
ORGANISM(S): Homo sapiens 
2022-12-21 | GSE213995 | GEO
TranscriptomicsRegulation of transcriptomic profile by ZL0580 and JQ1
Epigenetic suppression and durable silencing of HIV represent a promising strategy to achieve ART-free remission, consistent with the “block and lock” HIV cure paradigm. BRD4 is a host epigenetic reader and plays a critical role in HIV transcriptional regulation. We previously identified ZL0580, a f...
ORGANISM(S): Homo sapiens 
2026-01-27 | GSE315344 | GEO
UnknownPlasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4+ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p Transfer.
Not available
S-EPMC8264662 | biostudies-literature
UnknownHarziachalasins A-G, polycyclic-fused cytochalasins from the endophytic fungus Trichoderma harzianum MLJ-4 with HIV latency reversal activity.
Not available
S-EPMC12790558 | biostudies-literature
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