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TranscriptomicsGene Expression Data Following Chronic Vehicle or Fluoxetine Treatment in Thirty Mouse Inbred Lines
In order to understand how biochemical and genetic differences correlate with treatment response, we measured depressive-like behavior, gene expression and the levels of thirty-six neurobiochemical analytes across a panel of genetically-diverse mouse inbred lines after chronic treatment with vehicle...
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-28644 | biostudies-arrayexpress
TranscriptomicsDietary folate depletion and repletion in A/J and C57BL/6J mice
Defects in homocysteine and folate metabolism are associated with increased risks for neural tube and congenital heart defects, cardiovascular disease and stroke, cancers, and neurodegeneration. In many but not all cases, dietary supplementation with folate significantly reduces the severity and in...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-9242 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice with hromosome substitution from A/J strain vs parental strains, and acute lung injury following ozone exposure
Mice with a chromosome substitution from A/J strain were compared to parental strains, and acute lung injury following ozone exposure was measured. The candidate gene identified by microarray and genome-wide scans was tested in knockout and pharmacologically altered mice.
ORGANISM(S): Mus musculus 
2007-04-25 | E-MEXP-17 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain regions (bed nucleus of the stria terminalis, hippocampus, hypothalamus, periaqueductal gray, and pituitary gland) in six mouse strains (129S6/SvEvTac, A/J, C57BL/6J, C3H/HeJ, DBA/2J, and FVB/NJ)
Gene expression patterns were determined from five brain regions (bed nucleus of the stria terminalis, hippocampus, hypothalamus, periaqueductal gray, and pituitary gland) in six mouse strains (129S6/SvEvTac, A/J, C57BL/6J, C3H/HeJ, DBA/2J, and FVB/NJ). At least two replicate samples per brain regio...
ORGANISM(S): Mus musculus 
2009-09-16 | E-GEOD-4734 | biostudies-arrayexpress
TranscriptomicsEffect of High Fat Diet on gene expression of liver from obesity-prone (C57BL/6J) and obesity-resistant (A/J) mice
Mice were fed for 2, 10 or 30 days with a normal chow (NC) or a high fat diet (HFD). At each time point, mice were sacrificed and liver samples were collected and immediately frozen in liquid nitrogen. Total RNA from each sample was further extracted, purified, quality-controled before and after amp...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-12409 | biostudies-arrayexpress
MetabolomicsPhysiological extremes of the human blood metabolome: A metabolomics analysis of highly glycolytic, oxidative, and anabolic athletes
Human metabolism is highly variable. At one end of the spectrum, defects of enzymes, transporters, and metabolic regulation result in metabolic diseases such as diabetes mellitus or inborn errors of metabolism. At the other end of the spectrum, favorable genetics and years of training combine to res...
2022-02-07 | MTBLS2104 | MetaboLights
ProteomicsStrain-specific peptide (SSP) standard: A genetically encoded quality control standard for isobaric tagging strategies
Isobaric tag-based sample multiplexing strategies are extensively used for global protein abundance profiling. However, such analyses are often confounded by ratio compression resulting from the co-isolation, co-fragmentation, and co-quantification of co-eluting peptides, termed “interference.” Rece...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-03 | PXD023203 | Pride
Tmtpro16 Faims Eclipse Rts-ms3 Sps-ms3 Founder strains 
UnknownPsychosocial Correlates of Nocturnal Blood Pressure Dipping in African Americans: The Jackson Heart Study.
Not available
S-EPMC4941591 | biostudies-literature
TranscriptomicsGene Expression Data from Prefrontal Cortex and Nucleus Accumbens from Inbred Strains of Mice
Catechol-O-methyltransferase (COMT) is an ubiquitously expressed enzyme that maintains basic biologic functions by inactivating catechol substrates. In humans, polymorphic variance at the COMT locus has been associated with modulation of pain sensitivity (Andersen & Skorpen, 2009) and risk for devel...
ORGANISM(S): Mus musculus 
2010-02-23 | E-GEOD-20160 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of eight genetically diverse strains of mice (129/SvImJ, A/J, Balb/cJ, C3H/HeJ, C57BL/6J, Cast/EI, DBA/2J, and FVB/NJ) infected with Streptococcus, part 2
To evaluate the effect of genetic background on the immune response to streptococcal infection, eight genetically diverse strains of mice (129/SvImJ, A/J, Balb/cJ, C3H/HeJ, C57BL/6J, Cast/EI, DBA/2J, and FVB/NJ) were infected with three doses of Streptococcus zooepidemicus (500, 5,000, or 50,000 col...
ORGANISM(S): Mus musculus 
2005-01-01 | E-TIGR-99 | biostudies-arrayexpress
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