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TranscriptomicsUse of an activated beta-catenin to identify Wnt/beta-catenin pathway target genes in C. elegans, including a subset of collagen genes expressed in late larval development
The Wnt signaling pathway plays a fundamental role during the development of metazoans, where it functions in the regulation of diverse processes including cell fate specification, cell migration, and stem cell renewal. Activation of the beta-catenin dependent or canonical Wnt signaling pathway upr...
ORGANISM(S): Caenorhabditis elegans 
2014-05-13 | E-GEOD-51502 | biostudies-arrayexpress
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
GenomicsHDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibroadipogenic progenitors in dystrophic muscles
Fibro-adipogenic progenitors (FAPs) are emerging cellular components of the skeletal muscle regenerative environment. The alternative functional phenotype of FAPs - either supportive of muscle regeneration or promoting fibro-adipogenic degeneration M-bM-^@M-^S is a key determinant in the pathogenesi...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-52062 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of male Fech mutant BALB/c mouse livers vs male control BALB/c livers
Comparison of gene expression in livers of male Fech mutant BALB/c mouse with livers of male control BALB/c
ORGANISM(S): Mus musculus 
2005-10-14 | E-MEXP-189 | biostudies-arrayexpress
UnknownChlorido(1-cyclo-pentyl-idene-4-ethyl-thio-semicarbazidato-κN,S)diphenyl-tin(IV).
Not available
S-EPMC2971835 | biostudies-literature
UnknownHepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells.
Not available
S-EPMC3776844 | biostudies-literature
UnknownRhodamine 6G hexa-chlorido-stannate(IV) acetonitrile disolvate.
Not available
S-EPMC2915129 | biostudies-literature
TranscriptomicsReference: MicroRNA expression profiling in adult mouse liver following BaP treatment [Agilent miRNA array]
We have investigated the effect of exposure to 150 mg/kg benzo(a)pyrene (BaP) for 3 days on mRNA and miRNA expression levels in adult mouse liver. We used Agilent miRNA array platforms to assess effects of BaP exposure on miRNA expression levels. Our results indicate a distinct lack of effect of BaP...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-19438 | biostudies-arrayexpress
MetabolomicsEcological adaptation and succession of human fecal microbial communities in an automated in vitro fermentation system
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbial communities is a major challenge, which can be addressed using in vitro fermenters hosting complex microbial comm...
2021-07-15 | MTBLS2531 | MetaboLights
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