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ProteomicsMulti-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | MassIVE
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownA ferret model of COPD-related chronic bronchitis.
Not available
S-EPMC5033751 | biostudies-literature
TranscriptomicsXist RNA is a potent suppressor of hematologic cancer in mice.
X-chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X-chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate tha...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43961 | biostudies-arrayexpress
UnknownThe UK clinical eye research strategy: refreshing research priorities for clinical eye research in the UK.
Not available
S-EPMC11226710 | biostudies-literature
TranscriptomicsGene expression changes during development of sunitinib resistance in renal cell carcinoma patient derived xenografts
Transcriptome analysis was used to identify gene expression changes during development of sunitinib resistance in a renal cell carcinoma patient-derived xenograft (PDX) model. During the response phase, tumors exhibited a 91% reduction in volume, characterized by induction of TNFRSF1A, TNFAIP3, NFK...
ORGANISM(S): Homo sapiens 
2015-12-17 | E-GEOD-76068 | biostudies-arrayexpress
UnknownChildhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study.
Not available
S-EPMC4578796 | biostudies-literature
UnknownEmergency medical services intervals and survival in trauma: assessment of the "golden hour" in a North American prospective cohort.
Not available
S-EPMC3008652 | biostudies-literature
UnknownCausal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.
Not available
S-EPMC3749935 | biostudies-literature
UnknownTamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis.
Not available
S-EPMC10673935 | biostudies-literature
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