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TranscriptomicsPLZF acts as a regulator of cell-cycle genes, restricting hematopoietic stem cell proliferation and prevents hematopoietic stem cell aging.
To uncover gene programs that are regulated by PLZF in the early hematopoietic compartment, we performed micro array-based gene expression analysis of wild-type (WT) or PLZF-mutant (Zbtb16lu/lu) KSLs. DNA-microarrays were used to define and compare the transcriptional profiles of KSL cells isolated...
ORGANISM(S): Mus musculus 
2016-06-29 | E-MTAB-3682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from wild type and Mt1(-/-)Mt2(-/-) double knock-out mice after nickel aerosol exposure for 3, 8, 24, 48, and 72 hrs
Wildtype and Mt1(-/-)Mt2(-/-) double knockout 129S1/SvImJ strain mouse lungs were compared in their response to nickel aerosol exposure at 3, 8, 24, 48, and 72 hrs.
ORGANISM(S): Mus musculus 
2006-08-02 | E-MEXP-816 | biostudies-arrayexpress
TranscriptomicsAssociation of childhood chronic physical aggression with a DNA methylation signature in adult human T cells
Chronic physical aggression (CPA) is characterized by frequent use of physical aggression from early childhood to adolescence. Observed in approximately 5% of males, it is associated with early childhood adverse environments. DNA methylation, a covalent modification of DNA, regulates genome function...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-50674 | biostudies-arrayexpress
TranscriptomicsDifferential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression
Animal and human studies suggest that inflammation is associated with behavioral disorders including aggression. We have recently shown that physical aggression of boys during childhood is strongly associated with reduced plasma levels of cytokines IL-1a, IL-4, IL-6, IL-8 and IL-10, later in early a...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-47193 | biostudies-arrayexpress
TranscriptomicsAn RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex
Purpose: To better understand the function of the various cell types of the brain, we prospectively purified neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendrocytes, myelinating oligodendrocytes, microglia, endothelial cells, and pericytes from mouse cerebral cortex. We g...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-52564 | biostudies-arrayexpress
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