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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
ProteomicsProteomic analysis of innate immune responses in Polg D257A macrophages challenged with Pseudomonas aeruginosa
Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacterial and viral infection, can further compromise mitochondrial func...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-14 | PXD062877 | Pride
Innate immunity Polg Mouse Bone marrow macrophage Mitochondrial dysfunction Pseudomonas aeruginosa 
UnknownNew directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.
Not available
S-EPMC10925728 | biostudies-literature
UnknownIL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma.
Not available
S-EPMC4630166 | biostudies-literature
UnknownPI3K GOF leads to dysregulation of T and B cells that both contribute to extrinsically driving activation and differentiation of other CD4<sup>+</sup> T cells.
Not available
S-EPMC12521957 | biostudies-literature
UnknownTargeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.
Not available
S-EPMC6126939 | biostudies-literature
UnknownCOMPASS identifies T-cell subsets correlated with clinical outcomes.
Not available
S-EPMC4569006 | biostudies-literature
UnknownSpectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma.
Not available
S-EPMC7889847 | biostudies-literature
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
TranscriptomicsTranscription profiling of mouse pressure overload induced cardiomyopathy time series
Expression profiles at various time points after surgical intervention for pressure-overload induced cardiac hypertrophy and failure.
ORGANISM(S): Mus musculus 
2004-06-30 | E-MEXP-105 | biostudies-arrayexpress
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