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TranscriptomicsRNA-Seq of Aged Polg Mutator Mouse Brains
We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg mutator mice. As part of this analysis, we generated RNA-Seq data from RNA isolated from one cerebral hemisphere of these mice. mRNA levels and protein abundance levels were compared in this study. 11 sa...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55188 | biostudies-arrayexpress
ProteomicsAlternative Reading Frame expression in POLG gene
POLGARF is an upstream Alternative Reading Frame in POLG gene partially overlapping POLG sequence. To obtain POLGARF peptide reference spectra POLGARF was overexpressed in HEK293T and HEK293F cells .
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016007 | Pride
Polg C1qbp Dual coding Uorf Leaky scanning Mir Cug 5’utr 
ProteomicsMouse PolG Mutant Proteome (label-free)
Understand mitochondrial DNA polymerase mutated in context of organ/cell function. Resulting in mitochondrial proteome landscape shift, DNA mutation and instability. Impact cardiac phenotypes in the POLG mutant mouse. Label free/spectral library data
ORGANISM(S): Mus musculus (Mouse) 
2025-02-11 | PXD039029 | Pride
Proteomics Liver Mitochondria Polg 
ProteomicsMouse PolG Mutant Liver Proteome
Understand mitochondrial DNA polymerase mutated in context of liver/orgfan/cell function. Resulting in mitochondrial proteome landscape shift, DNA mutation and instability. Impact metabolic phenotype in the POLG mutant mouse
ORGANISM(S): Mus musculus (Mouse) 
2025-02-11 | PXD033029 | Pride
Polg Mouse Heart Proteome Mitochondria Dna polymerase 
ProteomicsProteomic analysis of innate immune responses in Polg D257A macrophages challenged with Pseudomonas aeruginosa
Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacterial and viral infection, can further compromise mitochondrial func...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-14 | PXD062877 | Pride
Innate immunity Polg Mouse Bone marrow macrophage Mitochondrial dysfunction Pseudomonas aeruginosa 
GenomicsTranscriptomic analysis of WT and POLG mutator macrophages
Transcriptomic analysis of WT and POLG mutator macrophages
PRJNA721451 | ENA
TranscriptomicsTranscriptomic analysis of WT and POLG mutator macrophages
The goal of this study was to characterize gene expression profiles of wild-type (WT) and POLG D257A/D257A mutator (POLG mutator) macrophages at rest and 6 hours after lipopolysaccharide (LPS) challenge.
ORGANISM(S): Mus musculus 
2021-04-13 | GSE171960 | GEO
UnknownMetformin Restores Mitochondrial Function and Neurogenesis in POLG Patient-Derived Brain Organoids.
Not available
S-EPMC12822396 | biostudies-literature
UnknownA new pathogenic POLG variant.
Not available
S-EPMC9289853 | biostudies-literature
GenomicsThe single cell transcriptomic profiling in iPSC derived Midbrain Organoid of POLG Disease
The single cell transcriptomic profiling in iPSC derived Midbrain Organoid of POLG Disease
PRJNA1009590 | ENA
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