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TranscriptomicsTranscriptome profiling of liver samples of C/EBPß ∆uORF mice
Synthesis of the metabolic transcription factor C/EBPβ-LIP is stimulated by mTORC1, which critically depends on a short upstream open reading frame (uORF) in the C/EBPβ-mRNA. We tested if that reduced C/EBPβ-LIP expression due to genetic ablation of the uORF delays the development of age-associated ...
ORGANISM(S): Mus musculus 
2019-01-16 | E-MTAB-6435 | biostudies-arrayexpress
GenomicsTranscriptome profiling of liver samples of C/EBPß ∆uORF mice
Transcriptome profiling of liver samples of C/EBPß ∆uORF mice
PRJEB24709 | ENA
ProteomicsUpstream open reading frames regulate proto-oncogene translation and encode HLA-presented immunogenic tumor antigens
Upstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leucocyte antigen (HLA)-presented peptides and suggest their potential role in cancer cell ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025716 | Pride
Cancer Uorf Immunotherapy Immunopeptidomics Hla peptides 
TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
ProteomicsHuman medulloblastoma ASNSD1 uORF KO LC-MSMS
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD046091 | Pride
Human Lc-msms Medulloblastoma Knockout 
GenomicsRNA-seq assessment of quadriceps muscle and brown adipose tissue in PPARGC1A uORF-TAA mice
RNA-seq assessment of quadriceps muscle and brown adipose tissue in PPARGC1A uORF-TAA mice
PRJNA532445 | ENA
UnknownLoss-of-function uORF mutations in human malignancies.
Not available
S-EPMC5799362 | biostudies-literature
UnknownImpacts of uORF codon identity and position on translation regulation.
Not available
S-EPMC6755093 | biostudies-literature
TranscriptomicsRNA-seq assessment of quadriceps muscle and brown adipose tissue in PPARGC1A uORF-TAA mice
We report a mutant mouse in which the uORF encoded by the PPARGC1A gene is disrupted via mutation of its start codon (uORF-TAA mutation). RNA-seq was used to assess differential gene expression in uORF-TAA versus wild-type mice in two metabolically important tissues that express PPARGC1A: skeletal m...
ORGANISM(S): Mus musculus 
2019-06-01 | GSE129687 | GEO
UnknownuORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.
Not available
S-EPMC7068905 | biostudies-literature
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