Medulloblastoma

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Technology Type

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CHEBI ID

CHEBI:16077 (1)
CHEBI:22211 (1)
CHEBI:17822 (1)
CHEBI:15721 (1)
CHEBI:26271 (1)
CHEBI:25094 (1)
CHEBI:18237 (1)
CHEBI:22660 (1)
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CHEBI:32816 (1)
CHEBI:16027 (1)

Metabolite Name

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First Public Date

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Modelling Approach

Ordinary differential equation model (1)

Study status

Recruiting (2)

Lab affiliation

Head of the Curie Institute Mass Spectrometry Platform (4)
Department of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (3)
Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (2)
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (2)
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University Children's Hospital Zürich (2)
1)Department of Pediatrics III, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany. 2)Department of General, Visceral, Vascular and Transplant Surgery, Medical Faculty, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany. (1)
Attending Physician Medical Director, Brain Tumor Institute Principal Investigator, Center for Cancer and Immunology Research, Children Research Institute Associate Professor of Pediatrics - The George Washington University School of Medicine and Health Sciences Executive co-Chair, Childrens Brain Tumor Network www.CBTN.org (1)
Balgrist Campus Lengghalde 5 CH-8008 Zürich Switzerland (1)
Biosciences, Bioanalytical Research Labs, University of Salzburg, Salzburg, Austria (1)
Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA (1)
Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK (1)
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Department of Pediatrics, Division of Pediatric Hematology/Oncology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA (1)
Department of Pediatrics, Section of Hematology-Oncology Baylor College of Medicine Texas Children's Hospital Houston, Texas (1)
GlycoProteomics Laboratory, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo (1)
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Institute for Molecular Medicine I, Medical Faculty, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany (1)
Ist. G. Gaslini (1)
King Faisal Specialist Hospital and Research center Riyadh, Saudi Arabia (1)
Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland Department of Neurosurgery, Cantonal Hospital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland (1)
Manager, Biological Mass Spectrometry CORE (1)
Manager, Biological Mass Spectrometry Core (1)
Mass Spectrometry and Proteomics facility (LSMP) Institut Curie PSL Research University FRANCE (1)
Medical College of Wisconsin (1)
Neurosurgeon & Senior Scientist Developmental and Stem Cell Biology, The Hospital for Sick Children, Canada (1)

Keyword

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Study type

Transcription profiling by array (109)
Comparative genomic hybridization by array (18)
Methylation profiling by array (16)
RNA-seq of coding RNA (12)
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Genotyping by array (3)
RNA-seq of non coding RNA (3)
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Other (2)
RNA-seq of coding RNA from single cells (2)
Methylation profiling by high throughput sequencing (2)
Interventional (2)
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Human - High-throughput sequencing (1)
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DNA-seq (1)

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2006 (6)
2005 (3)
2003 (3)
2004 (2)
2000 (1)

Location

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Canada (1)

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Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Amino acid profiling)

2024-05-30 | MTBLS9836 | MetaboLights

Subgroup specific somatic copy number aberrations in the medulloblastoma genome [mRNA]

Affymetrix Human Gene 1.1 ST Array profiling of 285 primary medulloblastoma samples. Total RNA was extracted from primary medulloblastoma samples and hybridized to Affymetrix Human Gene 1.1 ST Arrays (24-Array Plates) according to the manufacturer's instructions.

ORGANISM(S): Homo sapiens

2012-07-26 | E-GEOD-37382 | biostudies-arrayexpress

mRNA Expression Profiling of pooled medulloblastoma samples

mRNA expression analysis of 4 different pools of medulloblastoma samples with characteristic cytogenetic aberrations Keywords: Genetic modification Comparison of tumor RNA 1 (equally represented, pooled mRNA of tumors with cytogenetic aberration 1) versus tumor RNA (equally represented, pooled mRN...

ORGANISM(S): Homo sapiens

2010-07-09 | E-GEOD-22823 | biostudies-arrayexpress

High-resolution copy number analysis of medulloblastoma

We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genome of 212 medulloblastomas, a malignant pediatric brain tumor. Focal amplifications of fifteen known oncogenes and focal deletions of twenty known tumor suppressor genes (TSG) were revealed, most not prev...

ORGANISM(S): Homo sapiens

2010-04-06 | E-GEOD-14437 | biostudies-arrayexpress

A mouse model of the most aggressive subgroup of human medulloblastoma

This SuperSeries is composed of the following subset Series: GSE33199: A mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2] GSE33200: A mouse model of the most aggressive subgroup of human medulloblastoma [HT_MG-430_PM] Refer to individual Series

ORGANISM(S): Mus musculus

2012-02-29 | E-GEOD-33201 | biostudies-arrayexpress

A mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]

Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures This study contrasts mouse medullablastomas from a range of mouse genetic models. For Shh-type medulloblastoma [dka001-005, 009, 033 and 034] and [dka050-057], spontaneous medulloblastom...

ORGANISM(S): Mus musculus

2012-02-29 | E-GEOD-33199 | biostudies-arrayexpress

Proteomics, post-translational modifications, and integrative analyses reveal heterogeneity of molecular mechanisms within medulloblastoma subgroups

Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Francois JP, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA,...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2018-07-20 | MSV000082644 | MassIVE

TAp73 is a marker of glutamine addiction in medulloblastoma

Not available

ORGANISM(S): Homo sapiens

ST000898 | MetabolomicsWorkbench

Proteogenomic Analysis of Medulloblastoma

In order to investigate medulloblastoma biology via its proteome, we undertook a super-SILAC quantitative proteomics survey using 41 clinical tissue samples spanning the 4 genomic subgroups and control cerebellum

ORGANISM(S): Homo sapiens (Human)

2018-06-10 | PXD008750 | Pride

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