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GenomicsTwo distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription
In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138 ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and the molecular basis for their coregulation remains largely unknown. Here we identify two prevalent RPG promoter types, b...
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-01 | E-GEOD-61596 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the effect of S78454, a pan histone deacetylase inhibitor, on megakaryopoiesis derived from human CD34+ cells
S78454 (Abexinostat, PCI-24781) is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia, whose mechanism is partially understood. We have tested its effect at doses reached in patients plasma o...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MTAB-1180 | biostudies-arrayexpress
GenomicsTwo Distinct Promoter Nucleosome Architectures at Protein-Coding Genes in Yeast
Previous studies indicate that eukaryotic promoters display a stereotypical chromatin landscape characterized by a well-positioned +1 nucleosome near the transcription start site and an upstream -1 nucleosome that together demarcate a nucleosome-free (or depleted) region. Here we present evidence th...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-05 | E-GEOD-73337 | biostudies-arrayexpress
UnknownThe Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment.
Not available
S-EPMC11906373 | biostudies-literature
UnknownPresentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology.
Not available
S-EPMC10495699 | biostudies-literature
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