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ProteomicsA nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes
To start examining the mechanisms by which THRB mediated the epigenetic changes, we performed immunoprecipitation (IP) of THRB in THRB-FLAG HepG2 cells with anti-FLAG antibody, followed by mass-spectrometry to identify THRB-binding proteins.
ORGANISM(S): Homo sapiens (Human) 
2022-03-25 | PXD030665 | Pride
Human Thrb interacting proteins Thrb-flag-hepg2 
TranscriptomicsA latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.
MicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely relevant in more specific settings, such as response to stress. Here we describe such a role for the mir-2...
ORGANISM(S): Mus musculus 
2011-06-18 | E-GEOD-30012 | biostudies-arrayexpress
TranscriptomicsThe X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner [Agilent array data]
Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of M-bM-^...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39473 | biostudies-arrayexpress
TranscriptomicsThe X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner
This SuperSeries is composed of the following subset Series: GSE39472: X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner [ChIP-Seq data] GSE39473: The X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner [Agil...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39222 | biostudies-arrayexpress
TranscriptomicsGene expression profile of Tet1 knockout mouse embryonic stem cells (mESCs)
Global gene expression profile of Tet1 knockout ES cells is compared to wild-type ES cells. All ES lines used are V6.5 (mix 129 C57BL6 backgound). 2 Tet1 KO mice compared to 1 Tet1 wild type mouse.
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-30748 | biostudies-arrayexpress
GenomicsX-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner [ChIP-Seq data]
Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of M-bM-^...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-39472 | biostudies-arrayexpress
TranscriptomicsBlimp1 expression predicts embryonic stem cell development in vitro
Comparing global transcriptional profile between standard or 2i derived ES cell lines. RNA extracted from established ES cell lines either from standard derivation condition or 2i derivation condition, all cultured without 2i after derivation.
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-31868 | biostudies-arrayexpress
MetabolomicsThe dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into dynamic clusters at the plasma membrane, in the cytoplasm and in the nucleus of human hepatocytes and adipocytes. Insu...
2022-12-05 | MTBLS6505 | MetaboLights
GenomicsChIP-Seq of chromatin marks at distal enhancers in Mouse Embryonic Stem Cells and adult tissues.
Enhancers are enriched by histone H3 lysine 4 mono methylation (H3K4me1). To gain insight into the relation between enhancers and developmental state, chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) was performed in several cell types to determine the genome-wide bi...
ORGANISM(S): Mus musculus 
2010-10-31 | E-GEOD-24164 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Tet1 knockout (T1KO), Tet2 knockout (T2KO) and Tet1/Tet2 double knockout (DKO) mouse embryonic stem cells.
Global gene expression profile of single and double mutant mouse ES cells were compared to wt ES cells. Two male Tet1 KO, one male Tet2 KO, two male double KO, two female double KO, two male WT and two female WT mouse ES cells were compared. Global gene expression profile of single and double knocko...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-42991 | biostudies-arrayexpress
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